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Table 3 Sensitivity analysis of not statistically significant randomized controlled trials

From: Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors’ conclusions

Subgroups Categories Point estimate
Relative risk
Confidence interval
Relative risk
≤0.94 >0.94 ≤0.75 >0.75
Study size (in patient years) <2000 patient-years
(n = 35)
16 (46%) 19 (54%) 25 (71%) 10 (29%)
≥2000 patient-years
(n = 57)
28 (49%) 29 (51%) 16 (28%) 41 (72%)
Primary versus secondary prevention Primary
(n = 13)
5 (38%) 8 (62%) 5 (38%) 8 (62%)
Secondary
(n = 79)
39 (49%) 40 (51%) 36 (46%) 43 (54%)
  ≤0.85 >0.85 ≤0.65 >0.65
Increase in potentially clinically meaningful thresholds (n = 92) 16 (17%) 76 (83%) 22 (24%) 70 (76%)