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Table 3 Sensitivity analysis of not statistically significant randomized controlled trials

From: Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors’ conclusions

Subgroups

Categories

Point estimate

Relative risk

Confidence interval

Relative risk

≤0.94

>0.94

≤0.75

>0.75

Study size (in patient years)

<2000 patient-years

(n = 35)

16 (46%)

19 (54%)

25 (71%)

10 (29%)

≥2000 patient-years

(n = 57)

28 (49%)

29 (51%)

16 (28%)

41 (72%)

Primary versus secondary prevention

Primary

(n = 13)

5 (38%)

8 (62%)

5 (38%)

8 (62%)

Secondary

(n = 79)

39 (49%)

40 (51%)

36 (46%)

43 (54%)

 

≤0.85

>0.85

≤0.65

>0.65

Increase in potentially clinically meaningful thresholds (n = 92)

16 (17%)

76 (83%)

22 (24%)

70 (76%)