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Table 5 Risk factors for mortality within 90 days of study entry among patients with confirmed tuberculosis (n = 139)

From: Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: a prospective cohort

 

Unadjusted hazard ratio

(95% CI)

Log-rank

Adjusted hazard ratio

(95% CI)

Log-rank

Age (for each year decrease)

1.01 (0.97–1.06)

0.545

  

Gender

 Female

1.00

0.093

1.00

0.205

 Male

2.17 (0.88–5.35)

 

1.80 (0.73–4.48)

 

ART status

 Current ART

1.00

0.922

  

 ART naive

1.18 (0.43–3.24)

   

 Interrupted ART

1.29 (0.32–5.18)

   

CD4 category (cells/uL)

 ≥150

1.00

0.261

  

 199–149

3.30 (0.74–14.75)

   

 50–99

1.58 (0.26–9.48)

   

 <50

2.92 (0.80–10.61)

   

HIV viral load (log copies/mL)

 <400

1.00

0.683

  

 ≥400

1.30 (0.37–4.48)

   

C-reactive protein (mg/L)

 <50

1.00

0.262

  

 ≥50

3.16 (0.42–23.47)

   

LAM-positive

 No

1.00

0.007

1.00

0.004

 Yes

3.56 (1.35–9.36)

 

4.20 (1.50–11.75)

 

RIF-resistant TB

 No

1.00

0.082

1.00

0.032

 Yes

4.90 (1.13–21.24)

 

8.41 (1.74–40.67)

 
  1. Abbreviations: ART antiretroviral therapy; CI confidence interval, LAM lipoarabinomannan, RIF rifampicin, TB tuberculosis, WHO World Health Organization