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Table 1 Details of candidate predictors of women in the PREP study and the proportion with missing values

From: Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models

Candidate predictor Women with early onset pre-eclampsia n = 954 Mean (SD) or n (%) Number of women with missing data n (%)
Maternal characteristics
 Maternal age (years), mean (SD) 30.2 (6.1) 2 (0.2%)
 Gestational age at diagnosis (weeks), mean (SD) 30.5 (2.9)
 Number of fetuses in pregnancya   
  Singleton 866 (91%)  
  Twins 83 (9%)
  Triplets 5 (1%)  
 Parity  
  0 551 (58%)  
  1 207 (22%)  
  2 109 (11%)  
  3 55 (6%)  
  4 20 (2%)  
  5 – 9 12 (1%)  
History
 Medical historyb   1 (0.1%)
  None 601 (63%)  
  At least one condition 251 (26%)  
  Two or more conditions 101 (11%)  
  Chronic hypertension 139 (15%) 10 (1.0%)
  Renal disease 30 (3%) 10 (1.0%)
  Previous history of pre-eclampsia 169 (43%) 558b
  Autoimmune disease 18 (2%) 32 (3.4%)
  Diabetes mellitus 109 (11%) 6 (0.6%)
Symptoms
 Symptoms of headache and/or visual disturbance 382 (41%) 28 (2.9%)
 Symptoms of epigastric pain, nausea and/or vomiting 202 (22%) 47 (4.9%)
 Symptoms of chest pain and/or breathlessness 60 (7%) 126 (13.2%)
Bedside examination and tests
 Systolic blood pressure (mmHg), mean (SD) 159 (19) 5 (0.5%)
 Diastolic blood pressure (mmHg), mean (SD) 99 (12) 5 (0.5%)
 Clonus 95 (17%) 403 (42.2%)
 Exaggerated tendon reflexes 147 (24%) 353 (37%)
 Oxygen saturation by pulse oximetry (%), mean (SD) 98 (2) 521 (54.6%)
 Oxygen saturation: abnormal (< 94%) 4 (1%) 521 (54.6%)
Urine dipstick   
  None/Trace 39 (4%)  
  1+ 170 (18%)  
  2+ 314 (34%) 19 (2%)
  3+ 306 (33%)  
   ≥ 4 106 (11%)  
Laboratory tests
 Haemoglobin (g/L), mean (SD) 11.9 (1.3) 37 (3.9%)
 Platelet count (× 109/L), mean (SD) 226 (78) 41 (4.3%)
 Alanine transaminase (U/L), mean (SD) 31.0 (71.0) 75 (7.9%)
 Serum uric acid (μmol/L), mean (SD) 0.6 (2.7) 165 (17.3%)
 Serum urea (mmol/L), mean (SD) 4.6 (4.4) 70 (7.3%)
 Serum creatinine (μmol/L), mean (SD) 61.0 (17.8) 38 (4%)
 Urine PCR (mg/mmol), mean (SD) 273 (492) 109 (11.4%)
Treatment provided
 Any anti-hypertensive therapyc 753 (79%) 6 (0.6%)
 Oral anti-hypertensive therapy 734 (77%) 6 (0.6%)
 Parenteral anti-hypertensive therapy 111 (12%) 6 (0.6%)
 Parenteral magnesium sulfated 144 (15%) 6 (0.6%)
  1. aNumber of pregnancies
  2. bAll missing values are for nulliparous women where previous occurrence of pre-eclampsia is not applicable
  3. cOn-going at diagnosis or introduced within 1 day of diagnosis
  4. dAdministered any time before diagnosis or within 24 h of diagnosis