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Table 2 Performance of the PREP-S (risk at various time points) and PREP-L (overall risk by discharge) models in the derivation cohort and the external validation datasets for prediction of complications in women with early onset pre-eclampsia

From: Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models

Model performance Development cohort External cohorts
PREP PIERS PETRA
PREP-S model N = 946 N = 339  
C-statistic (95% CI)   
 At 48 hours 0.84 (0.81–0.87)b 0.75 (0.69–0.81)a  
 At 1 week 0.79 (0.76–0.81)b 0.72 (0.68–0.76)a  
 Overall 0.75 (0.73–0.78)b,c 0.71 (0.67–0.75)a  
Calibration slope (95% CI)   
 At 48 hours 1 0.80 (0.62–0.99)  
 At 1 week 1 0.75 (0.61–0.89)  
 Overall 1 0.67 (0.56–0.79)  
PREP-L model N = 946 N = 437 N = 211
C-statistic (95% CI) 0.82 (0.80, 0.84)b,d 0.81 (0.77–0.85)a 0.75 (0.64–0.86)a
Calibration slope (95% CI) 1 0.93 (0.72–1.13) 0.90 (0.48–1.32)
  1. CI confidence interval; N number of women analysed; PREP PRediction of complications in Early-onset Pre-eclampsia study; PIERS Pre-eclampsia Integrated Estimate of RiSk study; PETRA Pre-Eclampsia TRial Amsterdam study
  2. aApparent C-statistic
  3. bOptimism adjusted C-statistic
  4. cOverall apparent C-statistic 0.77 (95% CI 0.75, 0.79)
  5. dApparent C-statistic 0.84 (95% CI, 0.82–0.87)