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Table 2 Mean (95% CI) anti-LPS and anti-flagellin immunoglobulin levels in controls by sex, age at blood collection, and other baseline characteristics

From: Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study

Characteristic Anti-LPS IgG + IgA 95% CI Anti-Flagellin IgG + IgA 95% CI Anti-LPS IgG + Anti-Flagellin IgG 95% CI Anti-LPS IgA + Anti-Flagellin IgA 95% CI Anti-LPS IgG + IgA + Anti-Flagellin IgG + IgA 95% CI
Sex
 Female 3.78 3.37 4.19 3.18 2.82 3.54 3.37 3.00 3.74 3.59 3.15 4.02 6.96 6.23 7.68
 Male 3.58 3.32 3.85 3.24 3.01 3.48 3.11 2.88 3.35 3.71 3.43 3.99 6.82 6.35 7.29
P value* 0.425    0.771    0.249    0.639    0.762   
Age at blood collection, years
 ≤55 3.64 3.21 4.07 3.11 2.72 3.49 3.26 2.87 3.65 3.48 3.02 3.94 6.75 5.97 7.52
 55.1–60 3.40 2.93 3.87 3.24 2.82 3.66 2.99 2.57 3.42 3.64 3.15 4.14 6.64 5.80 7.47
 60.1–65 3.56 3.15 3.96 3.13 2.77 3.48 3.10 2.73 3.46 3.58 3.16 4.01 6.68 5.96 7.40
 >65 4.01 3.53 4.48 3.48 3.06 3.90 3.44 3.01 3.86 4.05 3.55 4.56 7.49 6.64 8.34
P value* 0.218    0.270    0.499    0.131    0.215   
BMI, kg/m2
 ≤25 3.39 2.98 3.79 3.02 2.65 3.38 3.04 2.68 3.40 3.37 2.93 3.80 6.41 5.68 7.13
 25.1–29.9 3.55 3.23 3.87 3.24 2.95 3.52 3.03 2.75 3.32 3.75 3.41 4.09 6.78 6.21 7.35
 ≥30 4.11 3.67 4.55 3.44 3.04 3.83 3.67 3.28 4.06 3.88 3.41 4.35 7.55 6.76 8.34
P value* 0.019    0.123    0.022    0.114    0.036   
Waist-to-hip ratio (WHR)
 <0.92 (M)/<0.77 (W) 3.35 2.98 3.73 3.15 2.81 3.49 2.98 2.64 3.32 3.53 3.12 3.93 6.50 5.83 7.18
 0.92–0.97 (M)/0.77–0.84 (W) 3.77 3.41 4.14 3.21 2.89 3.54 3.27 2.93 3.60 3.72 3.33 4.11 6.99 6.33 7.64
 >0.97 (M)/>0.84 (W) 3.80 3.40 4.20 3.31 2.96 3.67 3.34 2.98 3.70 3.78 3.35 4.21 7.12 6.40 7.83
P value* 0.110    0.510    0.153    0.401    0.221   
CRP, mg/L
 ≤1 3.40 3.03 3.76 3.09 2.75 3.42 3.02 2.69 3.36 3.46 3.06 3.86 6.48 5.82 7.14
 1–5 3.68 3.25 4.12 3.39 2.99 3.78 3.27 2.88 3.66 3.80 3.33 4.27 7.07 6.29 7.85
 >5 3.95 3.36 4.53 3.33 2.80 3.86 3.17 2.65 3.70 4.10 3.47 4.74 7.28 6.23 8.32
P valuea 0.098    0.326    0.493    0.077    0.156   
  1. *All P values are based on a test of linear trend, except P values for heterogeneity by sex, smoking status, and lifetime alcohol drinking pattern
  2. aAvailable for 100 controls