Biomarker | IRR (95% CI) | OR per ↑1 unit | ||||
---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | P trend | ||
Anti-LPS IgG + IgA, n case/control | 20/35 | 25/34 | 35/35 | 59/35 | ||
Matching factorsa | Ref. | 1.34 (0.61–2.98) | 2.74 (1.13–6.65) | 11.17 (3.46–36.00) | <0.0001 | 2.19 (1.59–3.03) |
Multivariableb | Ref. | 1.64 (0.56–4.83) | 2.52 (0.76–8.39) | 17.16 (3.52–83.50) | 0.001 | 2.58 (1.65–4.03) |
+ dietary factorsc | Ref. | 1.65 (0.54–5.04) | 2.67 (0.77–9.31) | 20.06 (3.88–103.0) | 0.001 | 2.68 (1.69–4.23) |
+ Fischer’s ratiod | Ref. | 2.52 (0.70–9.08) | 2.17 (0.55–8.63) | 13.65 (1.91–97.80) | 0.017 | 2.05 (1.25–3.36) |
Anti-Flagellin IgG + IgA, n case/control | 22/34 | 25/36 | 37/35 | 55/34 | ||
Matching factorsa | Ref. | 1.09 (0.5–2.38) | 2.35 (1.03–5.37) | 7.11 (2.46–20.55) | <0.0001 | 2.18 (1.56–3.06) |
Multivariableb | Ref. | 1.05 (0.37–2.93) | 2.87 (1.00–8.20) | 7.78 (2.19–27.57) | 0.001 | 2.31 (1.51–3.54) |
+ dietary factorsc | Ref. | 1.21 (0.40–3.59) | 3.07 (1.05–9.01) | 6.72 (1.88–24.02) | 0.003 | 2.25 (1.47–3.47) |
+ Fischer’s ratiod | Ref. | 1.52 (0.43–5.37) | 4.37 (1.21–15.84) | 3.59 (0.79–16.35) | 0.025 | 1.80 (1.12–2.90) |
Anti-LPS IgG + Anti-Flagellin IgG, n case/control | 24/34 | 29/36 | 40/34 | 46/35 | ||
Matching factorsa | Ref. | 1.23 (0.58–2.63) | 2.11 (0.99–4.52) | 4.08 (1.43–11.64) | 0.006 | 2.02 (1.43–2.85) |
Multivariableb | Ref. | 1.40 (0.53–3.68) | 2.92 (1.06–8.06) | 5.80 (1.46–23.02) | 0.007 | 2.47 (1.56–3.91) |
+ dietary factorsc | Ref. | 1.43 (0.52–3.92) | 3.45 (1.18–10.07) | 5.37 (1.31–22.10) | 0.007 | 2.57 (1.60–4.12) |
+ Fischer’s ratiod | Ref. | 1.18 (0.39–3.60) | 3.89 (1.12–13.58) | 2.71 (0.42–17.29) | 0.056 | 1.97 (1.15–3.36) |
Anti-LPS IgA + Anti-Flagellin IgA, n case/control | 18/35 | 27/34 | 27/35 | 67/35 | ||
Matching factorsa | Ref. | 2.16 (0.82–5.72) | 2.23 (0.85–5.87) | 8.47 (3.01–23.86) | <0.0001 | 1.83 (1.43–2.36) |
Multivariableb | Ref. | 4.00 (0.96–16.63) | 4.91 (1.15–20.9) | 14.22 (3.02–66.90) | 0.001 | 1.99 (1.39–2.86) |
+ dietary factorsc | Ref. | 5.34 (1.21–23.68) | 4.73 (1.06–21.16) | 14.97 (3.04–73.50) | 0.001 | 1.98 (1.37–2.86) |
+ Fischer’s ratiod | Ref. | 2.65 (0.55–12.84) | 4.49 (0.94–21.6) | 8.40 (1.64–43.12) | 0.009 | 1.65 (1.11–2.45) |
Anti-LPS IgG + IgA + Anti-Flagellin IgG + IgA, n case/control | 23/34 | 22/35 | 37/35 | 57/35 | ||
Matching factorsa | Ref. | 0.97 (0.46–2.08) | 2.25 (1.03–4.91) | 8.72 (2.78–27.29) | <.00001 | 1.57 (1.31–1.88) |
Multivariableb | Ref. | 1.54 (0.59–4.02) | 2.78 (0.94–8.21) | 14.01 (2.99–65.60) | 0.001 | 1.72 (1.34–2.21) |
+ dietary factorsc | Ref. | 1.71 (0.63–4.68) | 2.78 (0.92–8.35) | 13.31 (2.78–63.70) | 0.002 | 1.71 (1.33–2.21) |
+ Fischer’s ratiod | Ref. | 1.75 (0.58–5.27) | 2.19 (0.63–7.66) | 11.76 (1.70–81.40) | 0.021 | 1.48 (1.13–1.94) |