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Table 1 Baseline characteristics of 357 patients with febrile urinary tract infection

From: Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women

  Randomized (n = 200) Not randomized (n = 157) P valuec
Antibiotic treatment for 7 days (n = 97) Antibiotic treatment for 14 days (n = 103)
Age (years) 60 (48–72) 61 (40–73) 63 (49–75) 0.277
Male sex 44 (45%) 42 (41%) 58 (37%) 0.247
Body mass index (kg/m2, mean, SD) 26.3 (5.2) 25.8 (4.5) 26.1 (4.9) 0.969
Urologic history
 Indwelling urinary catheter 3 (3%) 2 (2%) 12 (8%) 0.024
 Urinary tract disordera 28 (29%) 28 (27%) 52 (33%) 0.296
 Recurrent UTIb 19 (20%) 19/100 (19%) 47/147 (32%) 0.007
Comorbidity
 Diabetes mellitus 12 (12%) 17 (17%) 25 (16%) 0.709
 Malignancy 3 (3%) 5 (5%) 17 (11%) 0.012
 Heart failure 12 (12%) 6 (6%) 19 (12%) 0.340
 Cerebrovascular disease 5 (5%) 5 (5%) 13 (8%) 0.210
 Chronic renal insufficiency 3 (3%) 2 (2%) 10 (6%) 0.070
 COPD 10 (10%) 11 (11%) 23 (15%) 0.236
 Immunocompromised 3 (3%) 8 (8%) 14 (9%) 0.209
Signs and symptoms at presentation
 Presentation at emergency department 59 (61%) 68 (66%) 145 (92%) <0.001
 Antibiotic pretreatment 23 (24%) 29 (28%) 56 (36%) 0.048
 Fever duration, hours 30 (15–48) 36 (20–60) 48 (19–96) 0.081
 Dysuria 82/95 (86%) 78/102 (77%) 102/145 (70%) 0.019
 Flank pain 57/96 (59%) 67/102 (66%) 91/144 (63%) 0.914
 Suprapubic pain 51/96 (53%) 48/100 (48%) 72/145 (50%) 0.876
 Perineal pain 4/96 (4%) 7/98 (7%) 8/140 (6%) 0.986
 Shaking chills within previous 24 hours 63/97 (65%) 60/101 (59%) 102/149 (70%) 0.256
 Temperature > 38 °C 66 (68%) 76 (74%) 121 (77%) 0.226
 Systolic blood pressure (mm Hg, mean, SD) 132 (19) 132 (22) 129 (20) 0.324
 Pulse rate (beats/minute) 93 (17) 94 (19) 97 (19) 0.360
Outpatient treatment 45 (46%) 45 (44%) 23 (15%) <0.001
Positive urine culture 69 (71%) 68 (66%) 107 (68%) 0.944
Positive blood culture 20/88 (23%) 15/98 (15%) 45/153 (29%) 0.012
Positive urine and/or blood culture 75 (77%) 70 (68%) 118 (75%) 0.571
Initial intravenous dose(s) of antibiotics 48 (50%) 55 (53%) 133 (85%) < 0.001
  1. Data presented as number (%) or median (IQR)
  2. COPD chronic obstructive pulmonary disease, UTI urinary tract infection
  3. aAny functional or anatomical abnormality of urinary tract except urinary catheter
  4. bThree or more UTIs in past 12 months or two or more UTIs in past 6 months
  5. cRandomized (both 7 and 14 days ciprofloxacin) vs. not-randomized patients