Table 2 Minimally adjusted associations of antidepressant use with 10-year cognitive changes
MMSE \( \sqrt{30-\mathrm{MMSE}} \) N = 7364 | BVRT \( \sqrt{15-\mathrm{BVRT}} \) N = 7262 | Isaac’s test N = 7291 | TMTA ln(TMTA) N = 6090 | TMTB ln(TMTB) N = 5857 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | |
Antidepressant | 0.14 | <0.0001 | <0.0001 | <0.0001 | 0.004 | |||||
TCAs | 0.110 (0.064) | 0.08 | 0.224 (0.054) | <0.0001 | –5.96 (0.97) | <0.0001 | 0.170 (0.044) | 0.0001 | 0.094 (0.051) | 0.07 |
SSRIs | 0.069 (0.048) | 0.15 | 0.128 (0.041) | 0.002 | –3.41 (0.74) | <0.0001 | 0.131 (0.034) | 0.0001 | 0.117 (0.039) | 0.003 |
Others | –0.052 (0.086) | 0.55 | 0.095 (0.073) | 0.19 | –2.61 (1.34) | 0.05 | 0.141 (0.061) | 0.02 | 0.082 (0.071) | 0.25 |
Antidepressant*time | 0.53 | 0.56 | 0.20 | 0.39 | 0.33 | |||||
TCAs*time | 0.012 (0.014) | 0.38 | 0.006 (0.012) | 0.65 | 0.31 (0.15) | 0.04 | –0.011 (0.007) | 0.11 | –0.006 (0.009) | 0.48 |
SSRIs*time | 0.010 (0.011) | 0.36 | 0.013 (0.009) | 0.17 | 0.08 (0.12) | 0.50 | –0.002 (0.005) | 0.75 | –0.001 (0.006) | 0.83 |
Others*time | 0.016 (0.020) | 0.43 | 0.002 (0.018) | 0.89 | –0.06 (0.22) | 0.77 | 0.006 (0.010) | 0.53 | –0.022 (0.013) | 0.09 |