Fig. 1

Description of DNA methylation dynamics across melanoma progression. a Two-dimensional clustering analysis was performed on all samples (n = 75). Probes are in rows; samples (green, nevi; yellow, primary melanomas; blue, metastases) in columns. Note that both gains and losses of DNA methylation changes occur across stages. b Distribution of tumor-specific DNA methylation changes in all genomic compartments: promoter, body, 3'UTR, and gene-body, and in varying CpG content and neighborhood context classified in island, shore, shelf, and open-sea. c Distribution of metastasis-specific DNA methylation changes in all genomic compartments: promoter, body, 3'UTR, and gene-body and in varying CpG content and neighborhood context classified in island, shore, shelf, and open-sea. d DAVID functional annotation of the most significant biological process categories within the hyper- (right panel) and hypomethylated (left panel) genes showing a negative correlation between DNA methylation and gene expression values (primary primary tumors, meta metastases; P < 0.01)