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Fig. 2 | BMC Medicine

Fig. 2

From: Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

Fig. 2

Identification of DNA methylation markers in the progression of malignant melanoma. Box-plots represent pyrosequencing results in (a) the discovery cohort and (b) the independent validation cohort I, consisting of 19 primary melanomas and 23 metastases. The selected candidates display large differences in DNA methylation between primary melanomas and metastases (DGMB ≥ 0.25), and were supported by gene expression or DNA methylation data available within publicly available databases (Additional file 1: Tables S18; primary primary tumors, meta metastases; Student’s t-test: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).

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