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Table 1 Characteristics of the patients included in the discovery cohort

From: Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

Characteristics No. of patients %
All clinical samples
 Type   
  Benign 14 18.6
  Primary 33 44.0
  Metastatic 28 37.3
Nevi
 Sex   
  Male 9 64.2
  Female 5 35.7
 Mean age (range), years 20.6 (1–74)  
  ≤50 12 85.7
  ≥50 2 14.3
 Location   
  Head and neck 3 21.4
  Trunk 8 57.1
  Upper limbs 2 14.3
  Lower limbs 1 7.1
Primary melanoma
 Sex   
  Male 17 51.5
  Female 16 48.5
 Mean age (range), years 62.1 (34–84)  
  ≤50 10 30.3
  ≥50 23 69.7
 Breslow thickness, mm   
  0.01–1.0 5 15.2
  1.01–2.0 8 24.2
  2.01–4.0 10 30.3
  >4.0 10 30.3
 Clark level   
  I–III 3 9.1
  IV–V 30 90.9
 Ulceration   
  Absent 19 57.6
  Present 14 42.4
 Histological subtype   
  Superficial spreading malignant melanoma 33 100.0
 Location   
  Head and neck 5 15.6
  Trunk 11 34.4
  Upper limb 2 6.3
  Lower limb 14 43.8
 Event recurrence   
  Yes 14 43.8
  No 18 56.3
 Died of melanoma   
  Yes 10 31.3
  No 22 68.8
Metastatic melanoma
 Sex   
  Male 9 37.5
  Female 15 62.5
 Mean age (range), years 60.8 (31–89)  
  ≤50 8 33.3
  ≥50 16 66.7
 Breslow thickness, mm   
  0.01–1.0 0 0
  1.01–2.0 6 31.6
  2.01–4.0 9 47.4
  >4.0 4 21.1
 Clark level   
  I–III 2 9.5
  IV–V 19 90.5
 Ulceration   
  Absent 8 47.1
  Present 9 52.9
 Histological subtype   
  Superficial spreading malignant melanoma 28 100.0
 Location   
  Head and neck 2 10.5
  Trunk 4 21.0
  Upper limb 0 0
  Lower limb 13 68.4
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