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Table 1 Selected baseline characteristics of comparative randomized controlled trials and matched observational studies

From: Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis

Trial Year Age, years Male, % Diabetes, % Hypertension, % Dyslipidemia, % Current smoker, % Prior PCI, % Prior MI, % No. FU, years EF, % Study period Adjusting method
LE MANS [24] 2016 61.3 ± 8.4 73 17 70 60 NA NA 33 105 10 53.7 ± 6.7 2001–2004 Randomization
PRECOMBAT [10] 2015 62.7 ± 9.5 77 30 51.3 40 27.7 12.7 6.7 600 5 60.8 ± 8.5 2004–2009 Randomization
SYNTAX [11] 2014 65.6 ± 10.1 75.6 25.6 62.4 75.4 24 NA 25.4 705 5 NA 2005–2007 Randomization
Boudriot et al. [23] 2011 69 (63–73) 77 33 82 64 28 NA 14 201 5 65 (55–68) 2003–2009 Randomization
EXCEL [12] 2016 65.9 ± 9.5 77.5 28 73.9 69.3 20.8 15.9 16.9 1905 3 57.3 ± 9.0 2010–2014 Randomization
NOBLE [13] 2016 66.2 ± 9.4 76 15 66 78 22 20 NA 1184 5 60 (52–64) 2008–2015 Randomization
Zheng et al. [14] 2016 62.2 ± 9.1 82 31 64.3 59.1 53.6 9.7 38.1 4046 3 60.2 ± 8.2 2004–2010 Propensity score adjustment
Yu et al. [33] 2016 64 (57–70) 82.5 28.7 58.9 34.6 44.9 6.8 21.7 922 7.1 62 (54–68) 2003–2009 Propensity score adjustment
Lu et al. [32] 2016 69 ± 11 85.5 46 83 50 67 NA NA 478 4.3 49 ± 12 2004–2010 Propensity score adjustment
Wei et al. [41] 2016 71.0 ± 5.9 79 45.2 72.6 21.0 58.1 NA NA 126 1.3 48.8 ± 7.5 2012–2013 Multivariate adjusted
IRIS-MAIN registry-1 [15] 2016 61 ± 10 75.3 31.5 51.8 33.4 33.1 10.8 15.5 954 9.7 58 ± 11 1995–2002 Multivariate adjusted
IRIS-MAIN registry-2 [15] 2016 64 ± 9 74.4 38.4 54.8 34.6 27.2 12.3 13.3 1901 5.6 56 ± 11 2003–2006 Multivariate adjusted
IRIS-MAIN registry-3 [15] 2016 65 ± 9 79.1 42.5 65.9 50.3 25.9 13.4 12.2 2362 3 55 ± 11 2007–2013 Multivariate adjusted
Jeong et al. [28] 2013 60.8 ± 10 79.2 30.8 49.1 1.7 20.1 18.2 6.9 318 4.7 NA 2001–2009 Propensity matching
DELTA registry [16] 2012 66.8 ± 10.5 65 31.6 68.1 65.6 43 16.8 NA 1204 3.5 53.2 ± 11.4 2002–2006 Propensity matching
CREDO-Kyoto 2 [40] 2012 69.4 ± 9.2 77 45 85 NA 25 NA 16 1005 3 60.2 ± 13.4 2005–2007 Multivariate adjusted
Chang et al. [27] 2012 64 ± 8.7 72.6 35.8 53.2 33.2 26.3 14.7 12.6 380 4.2 40.1 ± 27.8 2003–2009 Propensity matching
Yi et al. [29] 2012 64.2 ± 8.3 82.7 31.3 62.5 NA NA NA NA 256 5 NA 2003–2007 Propensity matching
CUSTOMIZE registry [25] 2011 65.3 ± 10.5 76.3 33.5 68.2 54.3 48 22 31.2 346 3 52.1 ± 9.0 2002–2011 Propensity matching
Rittger et al. [34] 2011 65 ± 7 78 45 84 94 NA 22 18 286 1 55 ± 14 2004–2007 Propensity score adjustment
Asan-Multivessel Registry [31] 2011 NA NA NA NA NA NA NA NA 550 5.6 NA 2003–2005 Propensity score adjustment
Kang et al. [30] 2010 64.3 ± 10.3 71.4 41.9 67.6 52.4 48.6 NA NA 210 2.8 53.7 ± 13.1 2003–2006 Propensity matching
Mäkikallio et al. [39] 2009 70 ± 9 80 17 46 NA 18 3 NA 287 1 54 ± 11 2005–2007 Multivariate adjusted
MAIN-COMPARE registry [26] 2008 64 (56–70) 71.2 33 50 30.1 27.1 15.1 10 1084 3 61 (55–66) 2000–2006 Propensity matching
Ghenim et al. [35] 2009 79.6 ± 3.5 71.7 23.6 65.1 41.5 24.5 20.7 19.8 211 1 NA 2004–2006 Propensity score adjustment
White et al. [36] 2008 69.4 ± 1.7 77 27 76 77 17 NA NA 353 2 54 ± 11 2003–2007 Propensity score adjustment
Rodes-Cabau et al. [37] 2008 82 ± 2 63 26 72 82 6 8 59 249 2 56 ± 14 2002–2008 Propensity score adjustment
Palmerini et al. [38] 2007 78 (75–88) 66 26 73 47 39 NA NA 259 2 53 (25–78) 2003–2006 Propensity score adjustment
  1. Values are mean, median (interquartile range) or %. EF ejection fraction, FU follow-up, MI myocardial infarction, NA not available, PCI percutaneous coronary intervention
  2. Expanded study abbreviations are as follows: CREDO-Kyoto 2 = the Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) PCI/CABG Registry Cohort-2; CUSTOMIZE = the Appraise a Customized Strategy for Left Main Revascularization Registry; DELTA = the drug-eluting stent for left main coronary artery disease registry; EXCEL = the Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization trial; IRIS-MAIN = Interventional Research Incorporation Society-Left MAIN Revascularization registry; LE MANS = Study of UnprotectedLeft Main Stenting Versus Bypass Surgery; MAIN-COMPARE = Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization registry; NOBLE = The Nordic-Baltic-British left main revascularisation study; PRECOMBAT = the Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease trial; SYNTAX = the other Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial