Skip to main content

Advertisement

Table 2 Stratified analysis of each endpoint based on study design, duration of follow-up, and stent type

From: Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis

Endpoint Subgroup No. of study HR 95% LCI 95% UCI P value I 2 P_heterogeneity P_interaction
All-cause death Randomized trial 5 1.00 0.79 1.26 0.97 22.3 0.27 0.57
  Matched study 17 1.08 0.92 1.26 0.36 36.5 0.07  
  Long-term 17 1.05 0.92 1.20 0.44 35 0.08 0.93
  Midterm 5 1.02 0.6 1.74 0.95 37.1 0.17  
  Second-generation DES 3 1.05 0.78 1.42 0.75 47.7 0.15 0.99
  BMS or early-generation DES 19 1.05 0.91 1.22 0.50 33.3 0.08  
Cardiac death Randomized trial 4 1.00 0.72 1.39 0.99 20.5 0.29 0.62
  Matched study 5 1.08 0.51 2.29 0.83 77.9 0.001  
  Long term 8 1.09 0.72 1.65 0.67 73.1 < 0.001 0.31
  Mid term 1 0.28 0.03 2.70 0.27 NA NA  
  Second-generation DES 2 1.10 0.75 1.63 0.63 0 0.59 0.97
  BMS or early-generation DES 7 1.01 0.58 1.77 0.97 77.2 < 0.001  
MI Randomized trial 5 1.39 0.85 2.27 0.19 57.5 0.05 0.18
  Matched study 5 2.01 1.64 2.45 < 0.001 0 0.72  
  Long term 10 1.69 1.22 2.24 0.002 57.7 0.01 NA
  Mid term 0 NA NA NA NA NA NA  
  Second-generation DES 2 1.56 0.52 4.71 0.43 87.3 0.005 0.39
  BMS or early-generation DES 8 1.92 1.59 2.31 < 0.001 0 0.73  
Stroke Randomized trial 5 0.84 0.47 1.50 0.56 50.9 0.09 0.25
  Matched study 4 0.44 0.18 1.07 0.07 79.4 0.002  
  Long term 9 0.64 0.33 1.24 0.19 83.5 < 0.001 NA
  Mid term 0 NA NA NA NA NA NA  
  Second-generation DES 2 1.25 0.44 3.54 0.68 74.6 0.05 0.15
  BMS or early-generation DES 7 0.48 0.25 0.93 0.03 74.2 0.001  
Revascularization Randomized trial 5 1.68 1.40 2.02 < 0.001 0 0.53 0.10
  Matched study 15 3.52 2.07 5.99 < 0.001 93.8 < 0.001  
  Long term 18 2.57 1.68 4.92 < 0.001 93.5 < 0.001 0.17
  Mid term 2 8.69 3.33 22.69 < 0.001 0 0.93  
  Second-generation DES 3 2.26 1.23 4.15 0.008 86.2 0.001 0.72
  BMS or early-generation DES 17 2.92 1.80 4.75 < 0.001 93.4 < 0.001  
Death/MI/stroke Randomized trial 3 0.96 0.80 1.15 0.66 0 0.86 0.43
  Matched study 14 1.10 0.99 1.22 0.08 39.5 0.06  
  Long term 14 1.07 0.97 1.17 0.16 36.4 0.09 0.48
  Mid term 3 0.89 0.58 1.38 0.61 11.9 0.32  
  Second-generation DES 2 0.96 0.80 1.15 0.69 0 0.62 0.52
  BMS or early-generation DES 15 1.10 0.99 1.22 0.09 35.3 0.09  
MACCE Randomized trial 5 1.20 1.00 1.44 0.05 44.6 0.13 0.31
  Matched study 11 1.57 1.14 2.17 0.006 87.7 < 0.001  
  Long term 12 1.50 1.18 1.91 0.001 86.7 < 0.001 0.39
  Mid term 4 1.07 0.52 2.19 0.86 80.2 0.002  
  Second-generation DES 3 1.35 1.15 1.59 < 0.001 28.6 0.25 0.93
  BMS or early-generation DES 13 1.42 1.05 1.92 0.02 87.3 < 0.001  
  1. BMS bare-metal stent, DES drug-eluting stent, HR hazard ratio, LCI lower 95% confidence interval, MACCE major adverse cardiac and cerebrovascular event, MI myocardial infarction, NA not applicable, UCI upper 95% confidence interval