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Table 5 The effect of the intervention (disease management versus usual care) on other secondary outcome and process endpoints, adjusted for baseline characteristics

From: Disease management in the treatment of patients with chronic heart failure who have universal access to health care: a randomized controlled trial

Endpoint Adjusted odds ratio (95% confidence interval)a
Depression symptomsb 0.688 (0.528 to 0.897)
Health-related quality of lifec
 Physical component summary 1.531 (1.165 to 2.011)
 Mental component summary 1.571 (1.253 to 1.971)
NYHA functional classd 1.477 (1.107 to 1.972)
6-minute walk teste 1.334 (0.929 to 1.915)
Adherence to treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blocking agentsf 1.010 (0.810 to 1.261)
Adherence to treatment with beta adrenergic receptor blocking agentsf 0.933 (0.767 to 1.134)
  1. NYHA New York Heart Association
  2. aOdds ratios derived from non-linear mixed models, adjusted for study center; year at recruitment; study period; sex; baseline value of the endpoint variable, age, NYHA function classification, and 6-minute walk test
  3. bMeasured with the nine-item patient health depression scale (PHQ-9). PHQ-9 score was classified as <10 (no or mild depression) and ≥10 (moderate-to-severe depression) [14]. Odds ratios were calculated for PHQ-9 score ≥10 during follow-up, tested in the ordered logistic non-linear mixed model
  4. cMeasured with 36-item short-form questionnaire (SF-36) [13]. Odds ratios were calculated for a ≥2.5 point increase in physical component summary and mental component summary scores
  5. dOdds ratios were calculated for a 1-class decrease in NYHA functional classification
  6. eOdds ratios were calculated for a ≥50 m increase in 6-minute walking distance
  7. fAdherence was defined as the number of treatment days covered according to defined daily dose and measured at 6-month intervals. The categories for number of days covered were: 0, 1–90, 91–150, 151–196 and >196. Odds ratios were calculated for attaining a category for number of days covered during follow-up, tested in the ordered logistic non-linear mixed model