Disease management in the treatment of patients with chronic heart failure who have universal access to health care: a randomized controlled trial

Table 5 The effect of the intervention (disease management versus usual care) on other secondary outcome and process endpoints, adjusted for baseline characteristics

Endpoint	Adjusted odds ratio (95% confidence interval)^a
Depression symptoms^b	0.688 (0.528 to 0.897)
Health-related quality of life^c
Physical component summary	1.531 (1.165 to 2.011)
Mental component summary	1.571 (1.253 to 1.971)
NYHA functional class^d	1.477 (1.107 to 1.972)
6-minute walk test^e	1.334 (0.929 to 1.915)
Adherence to treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blocking agents^f	1.010 (0.810 to 1.261)
Adherence to treatment with beta adrenergic receptor blocking agents^f	0.933 (0.767 to 1.134)

NYHA New York Heart Association
^aOdds ratios derived from non-linear mixed models, adjusted for study center; year at recruitment; study period; sex; baseline value of the endpoint variable, age, NYHA function classification, and 6-minute walk test
^bMeasured with the nine-item patient health depression scale (PHQ-9). PHQ-9 score was classified as <10 (no or mild depression) and ≥10 (moderate-to-severe depression) [14]. Odds ratios were calculated for PHQ-9 score ≥10 during follow-up, tested in the ordered logistic non-linear mixed model
^cMeasured with 36-item short-form questionnaire (SF-36) [13]. Odds ratios were calculated for a ≥2.5 point increase in physical component summary and mental component summary scores
^dOdds ratios were calculated for a 1-class decrease in NYHA functional classification
^eOdds ratios were calculated for a ≥50 m increase in 6-minute walking distance
^fAdherence was defined as the number of treatment days covered according to defined daily dose and measured at 6-month intervals. The categories for number of days covered were: 0, 1–90, 91–150, 151–196 and >196. Odds ratios were calculated for attaining a category for number of days covered during follow-up, tested in the ordered logistic non-linear mixed model

ISSN: 1741-7015