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Table 4 Univariable and multivariable analysis identifying factors associated with household transmitters

From: Recent household transmission of tuberculosis in England, 2010–2012: retrospective national cohort study combining epidemiological and molecular strain typing data

 

Household Transmitters

All other cases

Univariable analysis

Multivariable analysis

n

%

n

%

OR

CI

P value

aOR

CI

P value

Sex

 Male

292

53.5

13,375

57.0

0.87

0.73–1.03

0.097

0.89

0.72–1.10

0.273

Age group

 0–14

69

12.6

1059

4.5

3.11

2.36–4.11

<0.0001

2.56

1.58–4.15

<0.0001

 15–24

142

25.9

3529

15.0

1.93

1.55–2.38

1.47

1.14–1.91

0.003

 25–44

227

41.4

10,848

46.1

1.00

 

1.00

  

 45–64

83

15.2

4903

20.9

0.81

0.63–1.04

1.06

0.79–1.41

0.719

 65+

27

4.9

3172

13.5

0.41

0.27–0.61

0.51

0.32–0.82

0.005

Country of birth/Ethnicity

 White UK born

74

14.2

3308

15.0

1.40

1.02–1.93

0.037

1.46

0.97–2.20

0.069

 Black Caribbean UK born

6

1.2

268

1.2

1.40

0.61–3.25

0.427

1.21

0.51–2.89

0.666

 Black African UK born

27

5.2

335

1.5

5.06

3.22–7.93

<0.0001

2.26

1.15–4.44

0.018

 Indian UK born

21

4.0

551

2.5

2.39

1.47–3.90

<0.0001

2.08

1.17–3.69

0.013

 Pakistani UK born

35

6.7

655

3.0

3.35

2.23–5.03

<0.0001

2.76

1.65–4.62

<0.0001

 Bangladeshi UK born

5

1.0

110

0.5

2.85

1.13–7.18

0.026

2.75

0.94–8.03

0.064

 Other UK born

13

2.5

290

1.3

2.81

1.55–5.11

0.001

1.86

0.85–4.09

0.121

 India

80

15.4

5019

22.7

1.00

  

1.00

  

 Pakistan

54

10.4

2939

13.3

1.15

0.81–1.63

0.424

1.17

0.78–1.77

0.452

 Somalia

44

8.5

1186

5.4

2.33

1.60–3.38

<0.0001

1.74

1.10–2.76

0.019

 Bangladesh

7

1.3

813

3.7

0.54

0.25–1.17

0.120

0.81

0.34–1.90

0.620

 Nepal

15

2.9

583

2.6

1.61

0.92–2.82

0.093

1.26

0.67–2.35

0.471

 Nigeria

12

2.3

521

2.4

1.45

0.78–2.67

0.240

1.25

0.60–2.61

0.557

 Zimbabwe

14

2.7

456

2.1

1.93

1.08–3.43

0.026

1.69

0.87–3.25

0.119

 Philippines

2

0.4

355

1.6

0.35

0.09–1.44

0.147

0.30

0.04–2.19

0.233

 Kenya

5

1.0

302

1.4

1.04

0.42–2.58

0.935

1.25

0.49–3.19

0.635

 Sri Lanka

4

0.8

286

1.3

0.88

0.32–2.41

0.800

0.54

0.13–2.23

0.393

 Afghanistan

6

1.2

269

1.2

1.40

0.60–3.24

0.432

1.21

0.47–3.08

0.693

 Eritrea

8

1.5

250

1.1

2.01

0.96–4.20

0.064

1.66

0.74–3.73

0.221

 Romania

11

2.1

163

0.7

4.23

2.21–8.10

<0.0001

3.47

1.73–6.96

<0.0001

 Poland

6

1.2

165

0.8

2.28

0.98–5.31

0.055

2.12

0.88–5.13

0.094

 Other country

72

13.8

3296

14.9

1.37

0.99–1.89

0.055

1.21

0.82–1.80

0.329

Lineage

 Euro-American

173

42.4

4494

37.2

2.31

1.55–3.43

<0.0001

1.68

1.09–2.59

0.018

 CAS

117

28.7

3535

29.3

1.98

1.32–2.99

0.001

1.58

1.03–2.45

0.038

 EAI

29

7.1

1738

14.4

1.00

  

1.00

  

 Beijing

23

5.6

634

5.3

2.17

1.25–3.79

0.006

1.66

0.93–2.97

0.086

M. africanum

2

0.5

107

0.9

1.12

0.26–4.76

0.878

0.85

0.19–3.72

0.830

M. bovis

1

0.3

49

0.4

1.22

0.16–9.16

0.845

1.21

0.16–9.27

0.852

M. microti

0

0.0

1

0.0

1.00

  

1.00

  

 Multiple classifications

19

4.7

315

2.6

3.61

2.00–6.53

<0.0001

2.65

1.41–4.97

0.002

 Unknown

44

10.8

1198

9.9

2.20

1.37–3.54

0.001

1.70

1.03–2.81

0.038

  1. CAS Central Asian strain, EAI East African Indian