Skip to main content

Table 4 Univariable and multivariable analysis identifying factors associated with household transmitters

From: Recent household transmission of tuberculosis in England, 2010–2012: retrospective national cohort study combining epidemiological and molecular strain typing data

  Household Transmitters All other cases Univariable analysis Multivariable analysis
n % n % OR CI P value aOR CI P value
Sex
 Male 292 53.5 13,375 57.0 0.87 0.73–1.03 0.097 0.89 0.72–1.10 0.273
Age group
 0–14 69 12.6 1059 4.5 3.11 2.36–4.11 <0.0001 2.56 1.58–4.15 <0.0001
 15–24 142 25.9 3529 15.0 1.93 1.55–2.38 1.47 1.14–1.91 0.003
 25–44 227 41.4 10,848 46.1 1.00   1.00   
 45–64 83 15.2 4903 20.9 0.81 0.63–1.04 1.06 0.79–1.41 0.719
 65+ 27 4.9 3172 13.5 0.41 0.27–0.61 0.51 0.32–0.82 0.005
Country of birth/Ethnicity
 White UK born 74 14.2 3308 15.0 1.40 1.02–1.93 0.037 1.46 0.97–2.20 0.069
 Black Caribbean UK born 6 1.2 268 1.2 1.40 0.61–3.25 0.427 1.21 0.51–2.89 0.666
 Black African UK born 27 5.2 335 1.5 5.06 3.22–7.93 <0.0001 2.26 1.15–4.44 0.018
 Indian UK born 21 4.0 551 2.5 2.39 1.47–3.90 <0.0001 2.08 1.17–3.69 0.013
 Pakistani UK born 35 6.7 655 3.0 3.35 2.23–5.03 <0.0001 2.76 1.65–4.62 <0.0001
 Bangladeshi UK born 5 1.0 110 0.5 2.85 1.13–7.18 0.026 2.75 0.94–8.03 0.064
 Other UK born 13 2.5 290 1.3 2.81 1.55–5.11 0.001 1.86 0.85–4.09 0.121
 India 80 15.4 5019 22.7 1.00    1.00   
 Pakistan 54 10.4 2939 13.3 1.15 0.81–1.63 0.424 1.17 0.78–1.77 0.452
 Somalia 44 8.5 1186 5.4 2.33 1.60–3.38 <0.0001 1.74 1.10–2.76 0.019
 Bangladesh 7 1.3 813 3.7 0.54 0.25–1.17 0.120 0.81 0.34–1.90 0.620
 Nepal 15 2.9 583 2.6 1.61 0.92–2.82 0.093 1.26 0.67–2.35 0.471
 Nigeria 12 2.3 521 2.4 1.45 0.78–2.67 0.240 1.25 0.60–2.61 0.557
 Zimbabwe 14 2.7 456 2.1 1.93 1.08–3.43 0.026 1.69 0.87–3.25 0.119
 Philippines 2 0.4 355 1.6 0.35 0.09–1.44 0.147 0.30 0.04–2.19 0.233
 Kenya 5 1.0 302 1.4 1.04 0.42–2.58 0.935 1.25 0.49–3.19 0.635
 Sri Lanka 4 0.8 286 1.3 0.88 0.32–2.41 0.800 0.54 0.13–2.23 0.393
 Afghanistan 6 1.2 269 1.2 1.40 0.60–3.24 0.432 1.21 0.47–3.08 0.693
 Eritrea 8 1.5 250 1.1 2.01 0.96–4.20 0.064 1.66 0.74–3.73 0.221
 Romania 11 2.1 163 0.7 4.23 2.21–8.10 <0.0001 3.47 1.73–6.96 <0.0001
 Poland 6 1.2 165 0.8 2.28 0.98–5.31 0.055 2.12 0.88–5.13 0.094
 Other country 72 13.8 3296 14.9 1.37 0.99–1.89 0.055 1.21 0.82–1.80 0.329
Lineage
 Euro-American 173 42.4 4494 37.2 2.31 1.55–3.43 <0.0001 1.68 1.09–2.59 0.018
 CAS 117 28.7 3535 29.3 1.98 1.32–2.99 0.001 1.58 1.03–2.45 0.038
 EAI 29 7.1 1738 14.4 1.00    1.00   
 Beijing 23 5.6 634 5.3 2.17 1.25–3.79 0.006 1.66 0.93–2.97 0.086
M. africanum 2 0.5 107 0.9 1.12 0.26–4.76 0.878 0.85 0.19–3.72 0.830
M. bovis 1 0.3 49 0.4 1.22 0.16–9.16 0.845 1.21 0.16–9.27 0.852
M. microti 0 0.0 1 0.0 1.00    1.00   
 Multiple classifications 19 4.7 315 2.6 3.61 2.00–6.53 <0.0001 2.65 1.41–4.97 0.002
 Unknown 44 10.8 1198 9.9 2.20 1.37–3.54 0.001 1.70 1.03–2.81 0.038
  1. CAS Central Asian strain, EAI East African Indian