Fig. 2

Decision tree model: simplified treatment subtrees. HCWs healthcare workers, TB tuberculosis, LTBI latent TB infection, INH isoniazid. Path D Simplified treatment subtree, for patients who are treated for LTBI after test conversion. For HCWs who are inappropriately treated for LTBI after false-positive test conversions, the subtree is identical to the one displayed in Path D, with the exception that there is no benefit from treatment since workers do not truly have LTBI. These HCWs are no longer eligible for subsequent screens, leading to missed opportunities for prevention if true infection occurs in the future. Path E Subtree for LTBI not successfully treated. This relates to workers who receive no treatment, incomplete treatment, or unsuccessful treatment for latent TB infection. It is assumed that all active TB cases are diagnosed and fully treated