Fig. 5

One-way sensitivity analysis evaluating the impact of recognition of exposures on effectiveness (new active TB cases over 20 years). TB tuberculosis, TST Tuberculin Skin Test, QFT QuantiFERON®-TB-Gold. The proportion of exposures that are recognised strongly influences the relative effectiveness of the screening strategies. When most exposures are missed, the annual screening strategy is much more effective than both targeted screening and post-exposure screening only. However, as the proportion of recognised exposures increases, the targeted strategies become progressively more effective at preventing new active TB cases. Even if only 50% of exposures are recognised, annual screening with TST costs an estimated $927,242 per additional TB case prevented, relative to the targeted TST screening strategy