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Table 1 Top genes that were verified using bisulfite pyrosequencing

From: Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

Rank Gene symbol Gene Name Total CpGs analyzed Significant CpGs* Discovery Validation Presence of CpG island Correlation with mRNA expression
(Set 1) (Set 3)
1 FZD10 Frizzled-homologue 10 (CD350 antigen) 8 5 4 Yes Inverse
2 FAM83A Family with sequence similarity 83, Member A (Tumor Antigen BJ-TSA-9) 7 5 4 No Inverse
3 MYO18B Myosin-XVIIIb 3 3 2 No Inverse
4 MKX Homeobox protein Mohawk 4 4 1 Yes Inverse
5 GLI3 GLI Family Zinc Finger 3 6 5 0 Yes Direct
6 TMIGD2 Transmembrane and immunoglobulin domain-containing 2 (CD28 homologue) 5 4 0 No Direct
7 TMEM40 Transmembrane protein 40 6 6 0 No Direct
8 NEUROG3 Neurogenin-3 16 13 0 Yes Inverse
9 HOMER3 Homer protein homolog 3 7 6 0 No Direct
  1. *P < 0.05