| No. of cases | Fifths | | | Continuous per 10 cm |
---|
1 | 2 | 3 | 4 | 5 |
---|
Height, cm | HR | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) |
P for trend1
|
P for het.2
|
---|
Median (range) | | 165.2 (115.0–168.5) | 171.0 (168.5–173.0) | 175.0 (173.0–176.7) | 178.9 (176.7–181.0) | 184.2 (181.0–210.0) | | | |
Total prostate cancer | 7010 | 1.00 ref | 1.04 (0.96–1.12) | 1.02 (0.94–1.10) | 1.02 (0.94–1.10) | 1.06 (0.97–1.15) | 0.3 | | 1.02 (0.98–1.06) |
Grade |
Low-intermediate | 3740 | 1.00 ref | 0.96 (0.87–1.06) | 0.97 (0.88–1.08) | 0.91 (0.82–1.01) | 0.96 (0.86–1.08) | 0.2 | | 0.97 (0.92–1.03) |
High | 726 | 1.00 ref | 1.30 (1.02–1.66) | 1.39 (1.08–1.79) | 1.35 (1.04–1.74) | 1.54 (1.18–2.03) | 0.006 | 0.002 | 1.21 (1.06–1.38) |
Stage |
Localised | 2632 | 1.00 ref | 1.02 (0.91–1.15) | 1.01 (0.89–1.14) | 0.93 (0.82–1.06) | 1.01 (0.88–1.16) | 0.7 | | 0.98 (0.92–1.05) |
Advanced | 1387 | 1.00 ref | 1.04 (0.88–1.24) | 1.11 (0.92–1.32) | 1.13 (0.95–1.35) | 1.09 (0.90–1.32) | 0.4 | 0.2 | 1.06 (0.96–1.16) |
Prostate cancer deaths | 932 | 1.00 ref | 1.13 (0.92–1.39) | 1.17 (0.94–1.46) | 1.13 (0.91–1.41) | 1.43 (1.14–1.80) | 0.001 | | 1.17 (1.04–1.31) |
- Cox regression analysis. All models are stratified by centre and age at recruitment and adjusted for education level (less than university, university graduate, missing), smoking status (never, former, current, missing), marital status (married, not married, missing), diabetes (yes, no, missing), and physical activity (inactive, moderately inactive, moderately active, active, missing)
-
1
P values for trend are obtained by entering the continuous height in the model
-
2
P value from test for heterogeneity for the associations of height with risk of prostate cancer categorised according to prostate tumour grade (low-intermediate or high) and stage (localised or advanced)
- Low-intermediate grade (Gleason score of < 8, or grade coded as well, moderately, or poorly differentiated). High grade (Gleason score of ≥ 8, or grade coded as undifferentiated). Localised stage (TNM staging score of ≤ T2 and N0/Nx and M0, or stage coded in the recruitment centre as localised). Advanced stage (T3–T4 and/or N1–N3 and/or M1, and/or stage coded in the recruitment centre as metastatic)