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Fig. 5 | BMC Medicine

Fig. 5

From: Detection of antibiotic resistance is essential for gonorrhoea point-of-care testing: a mathematical modelling study

Fig. 5

Three-dimensional sensitivity analysis of the ratio of resistance spread between POC and NAAT. Shown are the ratios of resistance spread for MSM and HMW for ξ R,NAAT=0% and different values of ξ R,POC, λ A,baseline, and ψ (POC−R: ξ R,POC=0, POC+R: ξ R,POC>0). The shaded areas indicate that resistance spread is slower when using POC than when using NAAT. For the default values (ξ R,POC=99%, λ A,baseline=90%, and ψ=60%) and most other values shown, resistance spread is slower when using POC than when using NAAT. Each data point gives the median value over 1000 simulations (one per calibrated parameter set). Some calibrated parameter sets lead to the extinction of gonorrhoea in the simulation (Additional file 1: Figure S4). In these simulations, resistance did not spread and the ratio of resistance spread could not be calculated. Data points for these simulations were excluded from this figure since they would show the median ratio of resistance spread over less than 1000 simulations. HMW heterosexual men and women, MSM men who have sex with men, NAAT nucleic acid amplification test, POC point-of-care, POC + R POC test with resistance detection, POC − R POC test without resistance detection

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