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Table 1 Gonorrhoea testing and treatment parameters and their default values

From: Detection of antibiotic resistance is essential for gonorrhoea point-of-care testing: a mathematical modelling study

Parameter Description (unit) Baseline Culture NAAT POC+R POC−R
τ S Rate at which symptomatic individuals seek care (y−1) Variable a See baseline See baseline See baseline See baseline
τ A Rate at which asymptomatic individuals seek care (y−1) Variable a See baseline See baseline See baseline See baseline
ξ G Test sensitivity to detect gonorrhoea 99% b See baseline See baseline See baseline See baseline
ξ R Test sensitivity to detect resistance against the first-line antibiotic Any value 99% c 0% d 99% c 0% d
η 1, η 2 Efficacy of first-line (1) or second-line (2) antibiotic 99% e See baseline See baseline See baseline See baseline
δ Average time after test individuals return for treatment (days) 7 f See baseline See baseline 0 d 0 d
1/ω Average time individuals with resistant gonorrhoea wait for re-treatment (days) 7 c See baseline See baseline See baseline See baseline
λ A Fraction of asymptomatic individuals who return for treatment 90% c See baseline See baseline 100% d 100% d
λ S Fraction of symptomatic individuals who remain symptomatic after failed treatment 90% c See baseline See baseline See baseline See baseline
ψ Fraction of successfully treated individuals who were symptomatic at baseline 60% f
  1. Unless a value is set by definition, all values listed are default values and are varied in sensitivity analyses. Baseline: Resistance-free scenario (corresponds to scenario where culture or NAAT is used; ξ R can take any value since there is no resistance to detect). Culture, NAAT, POC−R, or POC+R refer to scenarios after resistance is introduced
  2. NAAT nucleic acid amplification test, POC point-of-care, POC+R POC test with resistance detection, POCR POC test without resistance detection
  3. aDerived
  4. b[35]
  5. cAssumption
  6. dBy definition
  7. e[23, 36]
  8. f[11]