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Fig. 1 | BMC Medicine

Fig. 1

From: Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Fig. 1

TIM3 expression is maintained on γδ T cells after drug treatment and parasite clearance. C57BL/6 mice were infected with P. chabaudi and then drug-treated with chloroquine and pyrimethamine. (a) Liver lymphocytes and (b) splenocytes were stained for TIM3 expression at different time points following end of drug cure to assess the percentage of TIM3+ γδ T cells, (c) and (d) number of TIM3+ γδ T cells, and (e) and (f) the total number of γδ T cells in the liver and spleen. The data represent three mice per time point and shows mean ± standard deviation (SD). Chronically P. chabaudi-infected mice (n = 8) were assessed on day 98 post-infection for TIM3+ γδ T cells in the (g) liver and (h) spleen. The data represent two independent experiments. Statistical analysis was performed using (a-f) paired t tests with Holm-Sidak method or (g) and (h) Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001

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