Fig. 3From: Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and NutritionStatistical significance of associations between metabolite concentrations and prostate cancer risk by time to diagnosis. a Five years or less between blood collection and diagnosis; n = 428 matched case-control sets. b More than 5 years between blood collection and diagnosis; n = 649 matched sets. Statistical significance was plotted as –log10(p values). The dashed and the dotted lines represent conventionally statistical significance and statistical significance after controlling the false discovery rate (Benjamini-Hochberg), respectively, both at α = 0.05. Filled circles represent positive associations, and unfilled circles represent inverse associations. The p values were derived from a conditional logistic regression using log metabolite concentration as a continuous variable and adjusting for exact age (continuously), body mass index (fourths; unknown), smoking (never; past; current; unknown), alcohol intake (<10; 10–19; 20–39; ≥40 g of alcohol per day; unknown), education (primary or none; secondary; degree level; unknown) and marital status (married or cohabiting; not married or cohabiting; unknown)Back to article page