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Fig. 4 | BMC Medicine

Fig. 4

From: Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition

Fig. 4

Odds ratios for high grade prostate cancer by concentration of selected metabolites. Tumours with Gleason score ≥8 or coded as undifferentiated were defined as high grade. Metabolites with p for linear trend <0.05 were included in the figure; no associations were statistically significant after controlling the false discovery rate at α = 0.05 (Benjamini-Hochberg). Odds ratios for one standard deviation increase in metabolite concentrations, 95% confidence intervals and p values for linear trend were derived from a conditional logistic regression using log metabolite concentration divided by the standard deviation of log metabolite concentration as a continuous variable and adjusting for exact age (continuously), body mass index (fourths; unknown), smoking (never; past; current; unknown), alcohol intake (<10; 10–19; 20–39; ≥40 g of alcohol per day; unknown), education (primary or none; secondary; degree level; unknown) and marital status (married or cohabiting; not married or cohabiting; unknown)

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