Fig. 5From: Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and NutritionOdds ratios for advanced stage prostate cancer by concentration of selected metabolites. Advanced stage tumours were defined as T3–4 and/or N1–3 and/or M1, using the tumour-node-metastasis staging system. Metabolites with p for linear trend <0.05 were included in the figure, and values marked in boldface were statistically significant after allowing for multiple testing using a false discovery rate controlling procedure at α = 0.05 (Benjamini-Hochberg). Odds ratios for one standard deviation increase in metabolite concentrations, 95% confidence intervals and p values for linear trend were derived from a conditional logistic regression using log metabolite concentration divided by the standard deviation of log metabolite concentration as a continuous variable and adjusting for exact age (continuously), body mass index (fourths; unknown), smoking (never; past; current; unknown), alcohol intake (<10; 10–19; 20–39; ≥40 g of alcohol per day; unknown), education (primary or none; secondary; degree level; unknown) and marital status (married or cohabiting; not married or cohabiting; unknown)Back to article page