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Table 1 Mendelian randomisation studies of the link between uricaemia and various cardiovascular diseases/risk factors with variants of SLCA9 as instrumental variables

From: Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options

Author year [ref]

Instrumental variable

No. of participants

Population

Main results

McKeigues 2009 [63]

SNP

1017

Orkney Islands Scottish

No effect on metabolic syndrome

Parsa 2012 [58]

SNP

516

Amish

Increase in ambulatory SBP, with low- and high-salt diets

Palmer 2013 [62]

SNP

>58,000

>10,000

Danes

No effect on BP or ischemic heart disease

Testa 2014 [61]

SNP

755

Southern Italy

Prediction of CKD progression

Mallamaci 2015 [59, 60]

SNP

449

Southern Italy

Increase in office SBP and US carotid atherosclerosis features

  1. BP blood pressure, SBP systolic blood pressure, SNP single nucleotide polymorphism, CKD chronic kidney disease, US ultrasonography