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Table 4 Hazard ratios for psoriasis in the regional breast cancer cohort according to genetic and lifestyle factors

From: Risk and predictors of psoriasis in patients with breast cancer: a Swedish population-based cohort study

  Total no. No. of cases HR (95% CI)
Model 1 Model 2
PRS score
 Tertile 1 1440 13 1.00 (Ref.) 1.00 (Ref.)
 Tertile 2 1442 36 2.74 (1.45–5.17) 2.83 (1.50–5.34)
 Tertile 3 1483 40 2.94 (1.57–5.49)* 2.98 (1.59–5.58)*
BMI
  < 25 kg/m2 2331 40 1.00 (Ref.) 1.00 (Ref.)
 25–30 kg/m2 1434 28 1.18 (0.73–1.92) 1.15 (0.71–1.87)
  > 30 kg/m2 536 19 2.29 (1.32–3.98) 2.10 (1.20–3.68)
Physical activity per week
 0 h 762 21 1.00 (Ref.) 1.00 (Ref.)
 0–2 h 1645 36 0.77 (0.45–1.33) 0.77 (0.44–1.32)
  > 2 h 1910 30 0.56 (0.32–0.98) 0.59 (0.33–1.03)
Regular smoker (cigarette smoking >1 year)
 No 1773 26 1.00 (Ref.) 1.00 (Ref.)
 Yes 2546 62 1.65 (1.04–2.61) 1.59 (1.00–2.52)
Alcohol consumption
 No 104 2 1.00 (Ref.) 1.00 (Ref.)
 Yes 2861 58 1.03 (0.25–4.22) 1.12 (0.27–4.70)
  1. Total no. number of breast cancer patients, No. of cases number of psoriasis cases, HR hazard ratio, CI confidence interval, BMI body mass index, PRS polygenic risk score
  2. Analyses were based on a subset of the regional cohort with information on genetic and lifestyle factors. Significant associations are denoted in boldface. Genetic predisposition for psoriasis was defined by a PRS including 35 genetic variants for psoriasis susceptibility. Patients were grouped into tertiles by their genetic risk. Model 1: adjusted for age and calendar period of breast cancer diagnosis. Model 2: all of the risk factors were put into the model, including radiotherapy and mastectomy. Missingness on all variables is <5%, except for alcohol consumption (32.1%, N = 1400). No evidence of non-proportional hazards was found
  3. *P for trend < 0.001, tested by log-linear trend test