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Table 2 Amino acid changes in genes involved in the humoral immune response after CPS immunization

From: Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

Gene PfNF135.C10 PfNF166.C8
Sequence changes Protein changes Sequence changes Protein changes
PF3D7_1036400
LSA-1
6 4 14 9
PF3D7_0108300 Conserved unknown 21 12 15 8
PF3D7_1033100
AdoMetDC/ODC
10 9 9 8
PF3D7_0108300
MSP2
13 7 8 7
PF3D7_0304600
CSP
6 6
A98G
S301N
K317E
E318Q
N321K
A361E
7 7
S301N
K314Q
K317E
E318K
N321K
K322T
E357Q
PF3D7_0509400
RNApol
6 4 9 6
PF3D7_0630600
Conserved unknown
7 2 8 3
PF3D7_0502400
MSP8
2 1 4 3
PF3D7_1147800
MAEBL
2 0 3 1
PF3D7_0703700
Conserved unknown
0 0 1 1
PF3D7_0829000
Conserved unknown
0 0 1 1
PF3D7_1212700
EIF3A
1 0 1 0
  1. Alterations in gene and protein sequences, based on whole genome sequencing, for 12 genes from NF135.C10 and NF166.C8 were compared to NF54. Single nucleotide polymorphisms and small insertions/deletions are shown together as sequence changes with expected changes in the in silico-translated protein sequence (counting altered amino acids). Changes in CSP protein sequence are indicated with single-letter amino acid code