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Table 2 Amino acid changes in genes involved in the humoral immune response after CPS immunization

From: Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

Gene

PfNF135.C10

PfNF166.C8

Sequence changes

Protein changes

Sequence changes

Protein changes

PF3D7_1036400

LSA-1

6

4

14

9

PF3D7_0108300 Conserved unknown

21

12

15

8

PF3D7_1033100

AdoMetDC/ODC

10

9

9

8

PF3D7_0108300

MSP2

13

7

8

7

PF3D7_0304600

CSP

6

6

A98G

S301N

K317E

E318Q

N321K

A361E

7

7

S301N

K314Q

K317E

E318K

N321K

K322T

E357Q

PF3D7_0509400

RNApol

6

4

9

6

PF3D7_0630600

Conserved unknown

7

2

8

3

PF3D7_0502400

MSP8

2

1

4

3

PF3D7_1147800

MAEBL

2

0

3

1

PF3D7_0703700

Conserved unknown

0

0

1

1

PF3D7_0829000

Conserved unknown

0

0

1

1

PF3D7_1212700

EIF3A

1

0

1

0

  1. Alterations in gene and protein sequences, based on whole genome sequencing, for 12 genes from NF135.C10 and NF166.C8 were compared to NF54. Single nucleotide polymorphisms and small insertions/deletions are shown together as sequence changes with expected changes in the in silico-translated protein sequence (counting altered amino acids). Changes in CSP protein sequence are indicated with single-letter amino acid code