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Table 1 Characteristics of the evaluated screening scenarios

From: Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting

Characteristics Considered variations
Eligibility criteria
Population: 50-74-30-15
Values arranged as (eligibility criteria of the NLST clinical trial)
age at begin smoking - age at quit smoking - minimum pack years - maximum years since quitting smoking 55-80-30-15
(as recommended by the US Preventive Services Task Force (USPSTF) for lung screening with LDCT [2])
50-75-15-9
(less restrictive eligibility criteria, similar to the NELSON trial)
55-75-40-10
(more restrictive eligibility criteria) [18]
Nodule management algorithm  
NELSON-like VDT cut = 400 days – V cut = 500 mm3
Scenario is characterised by the threshold value of the volume doubling time (VDT cut) and the cut-off volume (V cut) for cancer positive (values of the NELSON clinical trial)
VDT cut = 400 days – VDT cut = 300 mm3
VDT cut = 400 days – VDT cut = 400 mm3
VDT cut = 400 days – VDT cut = 750 mm3
VDT cut = 300 days – VDT cut = 500 mm3
VDT cut = 600 days – VDT cut = 500 mm3
VDT cut = 300 days – omitting VDT cut a
VDT cut = 400 days – omitting VDT cut a
VDT cut = 600 days – omitting VDT cut a
V fup = 80 mm3VDT cut = 400 days – VDT cut = 500 mm3 b
NLST-like Growth cut = 10% – D cut = 10 mm
Scenario is characterised by the threshold value of the tumour growth and the diameter (D cut) for cancer positive (values of the NLST clinical trial)
Growth cut = 10% – D cut = 9 mm
Growth cut = 10% – D cut = 11 mm
Growth cut = 7.5% – D cut = 10 mm
Tumour growth (threshold growth, Growth cut) is defined as a percentage increase in diameter Growth cut = 12.5% – D cut = 10 mm
Growth cut = 7.5% – omitting D cut a
Growth cut = 10% – omitting D cut a
Growth cut = 12.5% – omitting D cut a
D fup = 5 mm – Growth = 10% – D cut = 10 mmb
  1. aIn these scenarios nodule growth is taken as a single malignancy predictor
  2. bIn these scenarios a higher nodule size for the follow-up exams (V fup; D fup) is used according to the British Thoracic Society guidelines [29]. In other scenarios the value of nodule size for follow-up exams is applied according to the trials as 4 mm (NLST-like) and 50 mm3 (NELSON-like)