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Fig. 9 | BMC Medicine

Fig. 9

From: A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Fig. 9

Concentrations associated with a probability of ACPR28 of 0.95: model-predicted isobolograms by region and baseline parasitaemia. Asian patients = red, African patients = blue. Baseline parasitaemia 10,000 parasites/μL, solid isobole; baseline parasitaemia 100,000 parasites/μL, dotted isobole. Includes actual estimated individual exposures associated with Cure (ACPR28), open symbol or Failure (recrudescence), closed symbol

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