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A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

  • Fiona Macintyre1,
  • Yeka Adoke2,
  • Alfred B. Tiono3,
  • Tran Thanh Duong4,
  • Ghyslain Mombo-Ngoma5, 6, 7,
  • Marielle Bouyou-Akotet7,
  • Halidou Tinto8,
  • Quique Bassat9, 10, 11, 12, 13,
  • Saadou Issifou14,
  • Marc Adamy1,
  • Helen Demarest1,
  • Stephan Duparc1,
  • Didier Leroy1,
  • Bart E. Laurijssens15,
  • Sophie Biguenet1,
  • Afizi Kibuuka2,
  • Antoinette Kitoto Tshefu16,
  • Melnick Smith17,
  • Chanelle Foster17,
  • Illse Leipoldt17,
  • Peter G. Kremsner5, 6,
  • Bui Quang Phuc4,
  • Alphonse Ouedraogo3,
  • Michael Ramharter5, 6, 18, 19Email authorView ORCID ID profile and
  • on behalf of the OZ-Piperaquine Study Group
BMC Medicine201715:181

https://doi.org/10.1186/s12916-017-0940-3

Received: 1 May 2017

Accepted: 5 September 2017

Published: 9 October 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
1 May 2017 Submitted Original manuscript
29 May 2017 Reviewed Reviewer Report - Kasia Stepniewska
6 Jun 2017 Reviewed Reviewer Report - Sam Salman
9 Jun 2017 Reviewed Reviewer Report - Cor Jesus Fontes
2 Aug 2017 Author responded Author comments - Fiona Macintyre
Resubmission - Version 2
2 Aug 2017 Submitted Manuscript version 2
6 Aug 2017 Reviewed Reviewer Report - Cor Jesus Fontes
22 Aug 2017 Reviewed Reviewer Report - Kasia Stepniewska
4 Sep 2017 Author responded Author comments - Fiona Macintyre
Resubmission - Version 3
4 Sep 2017 Submitted Manuscript version 3
Publishing
5 Sep 2017 Editorially accepted
9 Oct 2017 Article published 10.1186/s12916-017-0940-3

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Medicines for Malaria Venture
(2)
Infectious Diseases Research Collaboration, Tororo Hospital
(3)
Centre National de Recherche et de Formation sur le Paludisme
(4)
National Institute of Malariology, Parasitology and Entomology
(5)
Centre de Recherches Médicales de Lambaréné
(6)
Institut für Tropenmedizin, Universität Tübingen
(7)
Universite des Sciences de la Sante Gabon, Département de Parasitology, Malaria Clinical and Operational Research Unit, Melen Hospital
(8)
Institut de Recherche en Sciences de la Santé – Unité de Recherche Clinique de Nanoro
(9)
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona
(10)
Centro de Investigação em Saúde de Manhiça (CISM)
(11)
ICREA
(12)
Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona)
(13)
Universidad Europea de Madrid
(14)
Centre de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance, Faculte Des Sciences De La Sante
(15)
BEL Pharm Consulting
(16)
Centre de Recherche du Centre Hospitalier de Mont Amba, Kinshasa School of Public Health, University of Kinshasa
(17)
QuintilesIMS, Department: Biostatistics
(18)
Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna
(19)
Bernhard Nocht Hospital for Tropical Diseases, Bernhard Nocht Institute for Tropical Medicine and University Medical Center Hamburg-Eppendorf

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