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Fig. 4 | BMC Medicine

Fig. 4

From: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Fig. 4

EPCR-binding PfEMP1 transcripts are lower in parasites from patients with cerebral malaria who died. Transcript units for CIDRα1-EPCR (sum of [CIDRa1.1-CIDRa1.8b]Tu-7), group A-EPCR (sum of [CIDRa1.4, CIDRa1.5a, CIDRa1.5b, CIDRa1.6b, and CIDRa1.7]Tu-4), group B-EPCR (sum of [CIDRa1.1, CIDRa1.8a, and CIDRa1.8b]Tu-2), CIDRα1.1, CIDRa1.4/6a, DBLa1ALL (all group A PfEMP1), DBLa1.5/6/8 types (group A PfEMP1 typically non-EPCR-binding), CIDRd (group A PfEMP1, non-EPCR-binding), and DBLa2/1.1/2/4/7 (group A PfEMP1, typically EPCR-binding). Transcript units of expression are shown on a logarithmic scale. The horizontal lines in red represent median values. Medians are compared by Mann-Whitney test. Survived (n = 87) and died (n = 11)

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