Skip to main content

Advertisement

Table 2 Transcript levels of var domains in children with severe malaria (SM, cerebral malaria and/or severe malarial anemia) and community children who were asymptomatic (AP)

From: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Primers PfEMP1 group SM (n = 145) AP (n = 14) P a
CIDRa1.1 BA 8.66 (1–39.2) 1 (1–1) 0.0001
CIDRa1.8a BA 1 (1–1.37) 1 (1–1) 0.18
CIDRa1.8b BA 1.07 (1–3.57) 1 (1–1) 0.006
Group B-EPCR binders   13.6 (2.73–44.2) 1 (1–1.23) <0.0001
CIDRa1.4/6a A 4.33 (1–13.0) 1 (1–1) 0.0001
CIDRa1.5a A 1 (1–2.10) 1 (1–1) 0.08
CIDRa1.5b A 1 (1–1) 1 (1–1) 0.09
CIDRa1.6b A 1 (1–1.53) 1 (1–1) 0.07
CIDRa1.7 A 2.42 (1–8.79) 1 (1–1) 0.004
Group A-EPCR binders   13.2 (3.94–34.7) 1 (1–1.06) <0.0001
CIDRα1-EPCR binders   34.7 (8.82–84.3) 1 (1–1.99) <0.0001
CIDR1d A 1 (1–3.65) 1(1–1) 0.005
DBLa1ALL A 40.2 (8.22–77.1) n = 144 1(1–1) <0.0001
DBLa1.5/6/8 types A 9.77 (3.28–21.2) n = 135 1(1–1) n = 10 <0.0001
DBLa2/1.1/2/4/7 types A 35.6 (20.8–60.1) n = 134 12.9 (6.18–19.3) n = 10 0.006
  1. aMedian transcript levels were compared using Mann-Whitney U test