Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Table 2 Transcript levels of var domains in children with severe malaria (SM, cerebral malaria and/or severe malarial anemia) and community children who were asymptomatic (AP)

Primers	PfEMP1 group	SM (n = 145)	AP (n = 14)	P ^a
CIDRa1.1	BA	8.66 (1–39.2)	1 (1–1)	0.0001
CIDRa1.8a	BA	1 (1–1.37)	1 (1–1)	0.18
CIDRa1.8b	BA	1.07 (1–3.57)	1 (1–1)	0.006
Group B-EPCR binders		13.6 (2.73–44.2)	1 (1–1.23)	<0.0001
CIDRa1.4/6a	A	4.33 (1–13.0)	1 (1–1)	0.0001
CIDRa1.5a	A	1 (1–2.10)	1 (1–1)	0.08
CIDRa1.5b	A	1 (1–1)	1 (1–1)	0.09
CIDRa1.6b	A	1 (1–1.53)	1 (1–1)	0.07
CIDRa1.7	A	2.42 (1–8.79)	1 (1–1)	0.004
Group A-EPCR binders		13.2 (3.94–34.7)	1 (1–1.06)	<0.0001
CIDRα1-EPCR binders		34.7 (8.82–84.3)	1 (1–1.99)	<0.0001
CIDR1d	A	1 (1–3.65)	1(1–1)	0.005
DBLa1ALL	A	40.2 (8.22–77.1) n = 144	1(1–1)	<0.0001
DBLa1.5/6/8 types	A	9.77 (3.28–21.2) n = 135	1(1–1) n = 10	<0.0001
DBLa2/1.1/2/4/7 types	A	35.6 (20.8–60.1) n = 134	12.9 (6.18–19.3) n = 10	0.006