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Table 2 Transcript levels of var domains in children with severe malaria (SM, cerebral malaria and/or severe malarial anemia) and community children who were asymptomatic (AP)
| Primers | PfEMP1 group | SM (n = 145) | AP (n = 14) | P a |
|---|---|---|---|---|
| CIDRa1.1 | BA | 8.66 (1–39.2) | 1 (1–1) | 0.0001 |
| CIDRa1.8a | BA | 1 (1–1.37) | 1 (1–1) | 0.18 |
| CIDRa1.8b | BA | 1.07 (1–3.57) | 1 (1–1) | 0.006 |
| Group B-EPCR binders | 13.6 (2.73–44.2) | 1 (1–1.23) | <0.0001 | |
| CIDRa1.4/6a | A | 4.33 (1–13.0) | 1 (1–1) | 0.0001 |
| CIDRa1.5a | A | 1 (1–2.10) | 1 (1–1) | 0.08 |
| CIDRa1.5b | A | 1 (1–1) | 1 (1–1) | 0.09 |
| CIDRa1.6b | A | 1 (1–1.53) | 1 (1–1) | 0.07 |
| CIDRa1.7 | A | 2.42 (1–8.79) | 1 (1–1) | 0.004 |
| Group A-EPCR binders | 13.2 (3.94–34.7) | 1 (1–1.06) | <0.0001 | |
| CIDRα1-EPCR binders | 34.7 (8.82–84.3) | 1 (1–1.99) | <0.0001 | |
| CIDR1d | A | 1 (1–3.65) | 1(1–1) | 0.005 |
| DBLa1ALL | A | 40.2 (8.22–77.1) n = 144 | 1(1–1) | <0.0001 |
| DBLa1.5/6/8 types | A | 9.77 (3.28–21.2) n = 135 | 1(1–1) n = 10 | <0.0001 |
| DBLa2/1.1/2/4/7 types | A | 35.6 (20.8–60.1) n = 134 | 12.9 (6.18–19.3) n = 10 | 0.006 |
