Table 2 Transcript levels of var domains in children with severe malaria (SM, cerebral malaria and/or severe malarial anemia) and community children who were asymptomatic (AP)

CIDRa1.1

BA

8.66 (1–39.2)

1 (1–1)

0.0001

CIDRa1.8a

BA

1 (1–1.37)

1 (1–1)

0.18

CIDRa1.8b

BA

1.07 (1–3.57)

1 (1–1)

0.006

Group B-EPCR binders

13.6 (2.73–44.2)

1 (1–1.23)

<0.0001

CIDRa1.4/6a

A

4.33 (1–13.0)

1 (1–1)

0.0001

CIDRa1.5a

A

1 (1–2.10)

1 (1–1)

0.08

CIDRa1.5b

A

1 (1–1)

1 (1–1)

0.09

CIDRa1.6b

A

1 (1–1.53)

1 (1–1)

0.07

CIDRa1.7

A

2.42 (1–8.79)

1 (1–1)

0.004

Group A-EPCR binders

13.2 (3.94–34.7)

1 (1–1.06)

<0.0001

CIDRα1-EPCR binders

34.7 (8.82–84.3)

1 (1–1.99)

<0.0001

CIDR1d

A

1 (1–3.65)

1(1–1)

0.005

DBLa1ALL

A

40.2 (8.22–77.1) n = 144

1(1–1)

<0.0001

DBLa1.5/6/8 types

A

9.77 (3.28–21.2) n = 135

1(1–1) n = 10

<0.0001

DBLa2/1.1/2/4/7 types

A

35.6 (20.8–60.1) n = 134

12.9 (6.18–19.3) n = 10

0.006