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Table 4 Spearman correlations between var transcript levels and markers of sequestration and endothelial activation in children with severe malaria (cerebral malaria, severe malarial anemia, or cerebral malaria + severe malarial anemia)

From: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

  sICAM-1 sVCAM-1 P-Selectin E-Selectin Ang-2 VWF PfHRP-2 Sequestered load sEPCR
CIDRα1.1 –0.02 n = 133 0.11 n = 133 0.07 n = 86 0.10 n = 133 0.03 n = 83 0.07 n = 122 –0.04 n = 144 0.03 n = 128 –0.06 n = 127
Group B-EPCR 0.003 n = 133 0.11 n = 133 0.07 n = 86 0.09 n = 133 0.06 n = 83 0.04 n = 122 –0.04 n = 144 –0.04 n = 141 –0.06 n = 127
CIDRα1.4/6a 0.03 n = 133 0.03 n = 133 0.02 n = 86 0.03 n = 133 0.08 n = 83 0.03 n = 122 0.009 n = 144 –0.01 n = 141 –0.10 n = 127
Group A-EPCR –0.03 n = 133 –0.02 n = 133 0.02 n = 86 –0.06 n = 133 0.01 n = 83 0.02 n = 122 0.02 n = 144 0.01 n = 141 –0.06 n = 127
CIDRα1-EPCR –0.01 n = 133 0.07 n = 133 0.05 n = 86 0.04 n = 133 0.05 n = 83 0.04 n = 122 –0.02 n = 144 –0.02 n = 141 –0.07 n = 127
CIDR1δ 0.04 n = 133 0.02 n = 133 0.09 n = 86 0.07 n = 133 –0.03 n = 83 0.006 n = 122 –0.04 n = 144 –0.004 n = 141 –0.14 n = 127
DBLα1ALL –0.06 n = 132 0.09 n = 132 0.001 n = 86 0.04 n = 132 0.06 n = 83 0.13 n = 121 0.002 n = 143 –0.005 n = 140 –0.12 n = 126
DBLα1.5/6/8 0.07 n = 123 0.08 n = 123 0.22 n = 80 0.01 n = 123 –0.04 n = 80 0.09 n = 112 –0.03 n = 134 0.006 n = 131 –0.12 n = 118
DBLα2/1.1/2/4/7 –0.06 n = 122 0.25 n = 122 P= 0.054 0.13 n = 80 0.05 n = 122 0.07 n = 80 0.13 n = 111 –0.07 n = 133 –0.07 n = 130 –0.03 n = 117
  1. P values for all correlations in table except DBLα2/1.1/2/4/7 and sVCAM-1 > 0.10.