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Table 4 Spearman correlations between var transcript levels and markers of sequestration and endothelial activation in children with severe malaria (cerebral malaria, severe malarial anemia, or cerebral malaria + severe malarial anemia)

From: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

 

sICAM-1

sVCAM-1

P-Selectin

E-Selectin

Ang-2

VWF

PfHRP-2

Sequestered load

sEPCR

CIDRα1.1

–0.02 n = 133

0.11 n = 133

0.07 n = 86

0.10 n = 133

0.03 n = 83

0.07 n = 122

–0.04 n = 144

0.03 n = 128

–0.06 n = 127

Group B-EPCR

0.003 n = 133

0.11 n = 133

0.07 n = 86

0.09 n = 133

0.06 n = 83

0.04 n = 122

–0.04 n = 144

–0.04 n = 141

–0.06 n = 127

CIDRα1.4/6a

0.03 n = 133

0.03 n = 133

0.02 n = 86

0.03 n = 133

0.08 n = 83

0.03 n = 122

0.009 n = 144

–0.01 n = 141

–0.10 n = 127

Group A-EPCR

–0.03 n = 133

–0.02 n = 133

0.02 n = 86

–0.06 n = 133

0.01 n = 83

0.02 n = 122

0.02 n = 144

0.01 n = 141

–0.06 n = 127

CIDRα1-EPCR

–0.01 n = 133

0.07 n = 133

0.05 n = 86

0.04 n = 133

0.05 n = 83

0.04 n = 122

–0.02 n = 144

–0.02 n = 141

–0.07 n = 127

CIDR1δ

0.04 n = 133

0.02 n = 133

0.09 n = 86

0.07 n = 133

–0.03 n = 83

0.006 n = 122

–0.04 n = 144

–0.004 n = 141

–0.14 n = 127

DBLα1ALL

–0.06 n = 132

0.09 n = 132

0.001 n = 86

0.04 n = 132

0.06 n = 83

0.13 n = 121

0.002 n = 143

–0.005 n = 140

–0.12 n = 126

DBLα1.5/6/8

0.07 n = 123

0.08 n = 123

0.22 n = 80

0.01 n = 123

–0.04 n = 80

0.09 n = 112

–0.03 n = 134

0.006 n = 131

–0.12 n = 118

DBLα2/1.1/2/4/7

–0.06 n = 122

0.25 n = 122 P  = 0.054

0.13 n = 80

0.05 n = 122

0.07 n = 80

0.13 n = 111

–0.07 n = 133

–0.07 n = 130

–0.03 n = 117

  1. P values for all correlations in table except DBLα2/1.1/2/4/7 and sVCAM-1 > 0.10.