Skip to main content
Fig. 3 | BMC Medicine

Fig. 3

From: Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

Fig. 3

O-PLS-DA score plots and loading plots. O-PLS-DA score plots and corresponding coefficient-coded loading plots obtained from metabolic profiles of 1H NMR spectra of the serum samples. The score plots display the first PLS component and one orthogonal component for each model. A two-way separation of the samples is demonstrated in all plots. The corresponding back-scaled loading plots reflect the class differences in the NMR spectra. Upright peaks indicate a relatively increased intensity of metabolites, and downright peaks a decreased intensity of metabolites. The colours shown on the plot are associated with the significance of metabolites in separating the samples; red indicating significance at a level of P < 0.05. (0), before first infusion of infliximab; (2), before second infusion; (6), before third infusion; (14), before fourth infusion. Glc glucose, Gln glutamine, GPC glycerophosphocholine, Gly glycine, HDL high-density lipoproteins, His histidine, Lac lactate, NAG N-acetyl glycoprotein, Phe phenylalanine, U1, U2, U3 unknown metabolite, Val valine, VLDL very-low density lipoproteins, CD Crohn’s disease, UC ulcerative colitis, Rem remission

Back to article page