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Table 2 Sensitivity and specificity of iPRM assay results for indicated study groups and subgroups

From: Rapid diagnosis of new and relapse tuberculosis by quantification of a circulating antigen in HIV-infected adults in the Greater Houston metropolitan area

   Sensitivitya
Smear-positive TB cases (n = 12) Smear-negative TB cases (n = 47)
  Sensitivity (n = 60)  
All TB cases (n = 60) 51/60 (85.0%, 73.4–92.9) 12/12 (100%, 73.5–100) 38/47 (80.9%, 66.1–90.6)
 Culture-positive TB (n = 48) 43/48 (89.6%, 77.3–96.5) 12/12 (100%, 73.5–100) 30/36 (83.3%, 66.5–93.0)
  PTB only (N = 20) 18/20 (90.0%, 68.3–98.8) 6/6 (100%, 54.1–100) 12/14 (85.7%, 57.2–98.2)
  EPTB only (N = 7) 7/7 (100%, 59.0–100) 7/7 (100%, 59.0–100)
  PTB and EPTB (N = 21) 18/21 (85.7%, 63.7–97.0) 6/6 (100%, 54.1–100) 12/15 (80.0%, 59.5–98.3)
 Culture-negative TB (n = 12) 8/12 (66.7%, 34.9–90.1) 7/11 (60.0%, 26.2–87.8)
  PTB only (N = 10) 7/10 (70%, 34.8–93.3) 6/9 (66.7%, 29.0–96.3)
  EPTB only (N = 2) 1/2 (50%, 1.3–98.7) 1/2 (50.0%, 1.3–98.7)
Relapse TB cases 7/9 (77.8%, 47.4–99.7) 3/3 (100%, 29.2–100) 4/6 (66.7%, 28.4–99.5)
  Specificity (n = 50)  
All non-TB controls (n = 50) 44/50 (88.0%, 75.7–95.5)   
 No history of previous TB (N = 35) 32/35 (91.4%, 76.9–98.2)
 History of previous TB (“cured TB,” N = 15) 12/15 (80.0%, 51.9–95.7)
  1. Data, n/N (%, 95 confidence interval)
  2. aOne culture-negative TB case was marked AFB-positive with a “rare bacilli” notation, but since this result could not be confirmed or determined to arise from a contamination event or other artifact, this sample was omitted when calculating iPRM assay sensitivity for smear-positive and smear-negative TB cases