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Table 2 Association between MGIT culture results by primary outcome isolated positives on MGIT and LJ culture results, smear results and TB symptoms. Data restricted to culture results at or after week 33

From: A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

Per protocol primary outcome MGIT result Paired smear result from same visit Paired LJ result from same visit Highest grade of TB symptoma reported within 7 days of patient visit
Negative Positive Total Negative Positive Total Absent or < Grade 1 Grade 1 (mild) Grades 2–4 Total
Favourable Negative 4659 (99%) 60 (1%) 4719 4456 (100%) 12 (<0.5%) 4468 3983 (85%) 453 (10%) 225 (5%) 4661
Positive 148 (93%) 11 (7%) 159 132 (87%) 19 (13%) 151 131 (82%) 20 (13%) 8 (5%) 159
χ2 test for independence    p < 0.0001    p < 0.0001     p = 0.481
Unfavourable Negative 336 (93%) 26 (7%) 362 331 (98%) 8 (2%) 339 240 (69%) 69 (20%) 40 (11%) 349
Positive 105 (25%) 309 (75%) 414 60 (15%) 336 (85%) 396 181 (45%) 116 (29%) 106 (26%) 403
χ2 test for independence    p < 0.0001    p < 0.0001     p < 0.0001
  1. aTB symptom as reported on REMoxTB CRF including any one of the following seven: cough, haemoptysis, fever, night sweats, shortness of breath, chest pains, unintentional weight loss