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Table 3 Association among patients with isolated post-treatment MGIT positive results between primary outcome and paired information smear results, LJ culture result, TB symptoms, days to positivity on MGIT and pattern of MGIT culture results. Data restricted to culture results at or after week 33

From: A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

   Per protocol primary outcome  
Paired information
N (%)
Favourable Unfavourable Total χ2 test for independence
Paired smear result from same visit Negative 148 (58%) 105 (42%) 253  
Positive 11 (3%) 309 (97%) 320 p < 0.0001
Paired LJ result from same visit Negative 132 (69%) 60 (31%) 192  
Positive 19 (5%) 336 (95%) 355 p < 0.0001
Highest grade of TB symptomb reported within 7 days of patient visit Absent or < Grade 1 131 (42%) 181 (58%) 312  
Grade 1 (mild) 20 (15%) 116 (85%) 136  
Grades 2–4 8 (7%) 106 (93%) 114 p < 0.0001
Days to positivity on MGIT <5 6 (5%) 127 (95%) 133  
5 to < 15 47 (19%) 202 (81%) 249  
15 to < 42 94 (57%) 72 (43%) 166 p < 0.0001
Pattern of MGIT results at visita Mixed 86 (73%) 32 (27%) 118  
1 positive 53 (30%) 122 (70%) 175  
≥2 positives 20 (7%) 260 (93%) 280 p < 0.0001
  1. aPatterns are as follows: All negative at least one negative result and no positive results at that visit, 1 positive a single positive result and no negative results at that visit, Mixed a single positive result and at least one negative result at that visit, ≥ 2 positives at least two positive results and no negative results at that visit
  2. bTB symptom as reported on REMoxTB CRF any one of the following seven: cough, haemoptysis, fever, night sweats, shortness of breath, chest pains, unintentional weight loss