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Table 2 Predictors of telomere length ranking between birth and young adulthood

From: Telomere tracking from birth to adulthood and residential traffic exposure

  Multi variable model
Predictors Change in ranking 95% CI P value
Early-life covariates
 Placental telomere length, + IQR –24.6 –29.4 to –19.9 <0.0001
 Newborn girls 9.9 0.8 to 19.0 0.04
 Birth weight, +IQR 1.3 –6.4 to 9.0 0.76
 Gestational age, +IQR –3.4 –10.2 to 3.4 0.34
 Parental education level –5.4 –10.5 to –0.4 0.04
 Smoking during pregnancy –8.3 –23.0 to 6.4 0.27
 Residential distance to major road early-life, 2-fold change 8.7 1.2 to 16.1 0.03
Adult covariates
 Age, +1 year –1.7 –3.2 to –0.3 0.03
 Smoking –8.3 –17.1 to 0.5 0.07
 Gamma-glutamyl transferase, +IQR –4.0 –7.4 to –0.7 0.02
  1. To examine telomere tracking over life we ranked telomere length at birth (based on placental telomere) and at adult life (based on buccal cell telomere length). We studied the difference in ranking, a negative difference in ranking between birth and young adulthood means a decline in ranking to 100 faster than the average of the population
  2. CI confidence interval, IQR interquartile range