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Table 2 Hazard ratios (HR) and 95% CI for associations of lipid biomarkers with total cancer mortality

From: Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC–Heidelberg cohort

Biomarker quartile_1 quartile_2 quartile_3 quartile_4 pval_med hr_con pval_con
TCa Ref 0.78 (0.60–1.00) 0.78 (0.61–1.01) 0.77 (0.59–0.99) 0.072 0.67 (0.47–0.95) 0.025
TC adjustedb Ref 0.74 (0.56–0.98) 0.77 (0.59–1.02) 0.71 (0.54–0.94) 0.036 0.62 (0.43–0.88) 0.009
Medianc 4.70/4.70/4.60 5.50/5.60/5.50 6.20/6.20/6.20 7.20/7.20/7.10    
No of cases 187 158 170 177    
HDL-Ca Ref 0.83 (0.66–1.03) 0.86 (0.69–1.08) 0.56 (0.43–0.73) <0.0001 0.67 (0.55–0.82) 0.0001
HDL-C adjustedb Ref 0.93 (0.73–1.18) 0.95 (0.74–1.22) 0.67 (0.50–0.91) 0.021 0.78 (0.62–0.98) 0.037
Medianc 0.95/0.90/1.20 1.20/1.10/1.50 1.50/1.40/1.80 2.00/1.80/2.10    
No of cases 254 188 188 103    
apo(a)a Ref 0.77 (0.60–0.97) 0.75 (0.59–0.95) 0.64 (0.50–0.82) 0.0007 0.56 (0.39–0.80) 0.001
apo(a) adjustedb Ref 0.76 (0.58–0.99) 0.80 (0.62–1.03) 0.71 (0.54–0.93) 0.029 0.67 (0.45–0.99) 0.044
Medianc 1.34/1.30/1.48 1.54/1.48/1.68 1.70/1.64/1.90 2.04/1.91/2.16    
No of cases 224 169 183 156    
apoB-100a Ref 0.84 (0.66–1.08) 0.73 (0.56–0.94) 0.87 (0.68–1.12) 0.284 0.82 (0.64–1.05) 0.112
apoB-100 adjustedb Ref 0.88 (0.68–1.15) 0.69 (0.52–0.91) 0.79 (0.60–1.03) 0.054 0.72 (0.56–0.93) 0.011
Medianc 0.82/0.84/0.77 1.03/1.07/0.97 1.21/1.26/1.15 1.47/1.53/1.38    
No. of cases 173 178 160 204    
TGa Ref 1.29 (1.00–1.67) 1.00 (0.77–1.29) 1.21 (0.94–1.56) 0.382 1.06 (0.95–1.19) 0.305
TG adjustedb Ref 1.28 (0.97–1.70) 0.92 (0.69–1.23) 1.10 (0.82–1.46) 0.895 0.97 (0.85–1.11) 0.675
Medianc 0.90/1.00/0.80 1.50/1.70/1.10 2.00/2.40/1.60 3.30/3.70/2.70    
No of cases 153 173 162 200    
Lp(a)a Ref 0.98 (0.77–1.25) 0.76 (0.59–0.98) 0.78 (0.60–1.00) 0.080 0.94 (0.90–0.99) 0.011
Lp(a) adjustedb Ref 0.94 (0.72–1.22) 0.73 (0.56–0.96) 0.74 (0.57–0.98) 0.076 0.94 (0.89–0.98) 0.010
Medianc 3.50/3.30/3.85 8.50/8.10/9.40 20.25/19.40/21.75 129.60/121.60/134.70    
No of cases 189 187 160 157    
  1. aCrude model adjusted for sex and age at blood draw
  2. bMultivariable model further adjusted for baseline height, waist, BMI, lifetime alcohol consumption, red meat intake, fiber intake, smoking status, socioeconomic status, physical activity, diabetes, hypertension, and use of lipid-lowering drugs
  3. cMedians of lipid parameters are of all/men/women within the cancer deaths
  4. Entries in boldface are statistically significant
  5. apo apolipoprotein, CI confidence interval, HDL-C high-density lipoprotein, hr_con continuous HR for a doubling in biomarker concentration, Lp(a) lipoprotein (a), pval_con P trend continuously, pval_med P trend over lipid biomarker levels based on the median of each quartile, TC total cholesterol, TG triglycerides