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Fig. 1 | BMC Medicine

Fig. 1

From: Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination

Fig. 1

Schematic diagram of HCV transmission compartmental model. Individuals are distributed in eight different risk groups (j): males and females for heterosexuals, for intravenous drug users, and for other groups, and low- and high-risk subgroups for men who have sex with men. New individuals enter the susceptible monoinfected categories (X) at a rate θ [20]. Susceptible individuals may be acutely infected (A) at an infection rate β j (estimated during the calibration process for each subgroup). Individuals acutely infected may progress to HCV chronic infection (C) at a rate (1–γ) or spontaneously clear their infection at a rate γ (S). Acute infection lasts an average 1/ψ. Chronically infected individuals start an HCV treatment at an annual rate τ. Treatment lasts an average 1/ω and results in SVR12 in a proportion α of all treated patients. Successfully treated patients or patients with spontaneous clearance may be reinfected with an external force of infection δ j

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