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Table 2 Interventions – key parameter values

From: Economic evaluation of type 2 diabetes prevention programmes: Markov model of low- and high-intensity lifestyle programmes and metformin in participants with different categories of intermediate hyperglycaemia

Intervention Annual cost of intervention (£, 2015) Incremental utility associated with intervention (QALY) Relative risk of developing T2DM
Pragmatic lifestyle programme Yr 1: £203.44 Yr 2: £80.02 0.0189 [Beta distribution, SE: 0.001] During intervention: IFG: 0.74/IGT: 0.74/HbA1c: 0.74 [Lognormal distribution, SE: 0.11]
Intensive lifestyle programme Yr 1: £1225 Yr 2: £689 Yr 3: £671 0.0189 [Beta distribution, SE: 0.001] During intervention: IFG: 0.63/IGT: 0.55/HbA1c: 0.71 [Lognormal distribution, SE: 0.10 (IFG), 0.07 (IGT), 0.10 (HbA1c)] Up to 7 years post- intervention: IFG: 0.80/IGT: 0.80/HbA1c: 0.71 [Lognormal distribution, SE: 0.06 (IFG), 0.06 (IGT), 0.10 (HbA1c)]
Metformin £124.25 0.0031 [Beta distribution, SE: 0.002] IFG: 0.82/IGT: 0.82/HbA1c: 0.62 [Lognormal distribution, SE: 0.05(IGT), 0.05 (IFG), 0.10 (HbA1c)]
  1. Parametric form and standard error of distribution used in probabilistic sensitivity analysis in italics
  2. Sources: Intervention costs (calculated – see Additional file 1: Appendix 2), incremental utilities [32], relative risks [8, 12, 15, 20, 21]