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Table 3 Incidence rates and hazard ratios (HRs) for associations of site-specific fracture with exposure to polymyalgia rheumatica (PMR) and giant cell arteritis (GCA)

From: Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study

Variables

Present

Non-present

Unadjusted HR (95% CI)

Adjusted HR (95% CI)a

 

Number with fracture

Rate per 10,000 person-years (95% CI)

Number with fracture

Rate per 10,000 person-years

  

PMR

 Wrist

464

40.67 (37.14–44.55)

1568

35.06 (33.37–36.84)

1.16 (1.05–1.29)

1.70 (1.52–1.90)

 Vertebra

276

24.19 (21.50–27.22)

482

10.78 (9.86–11.78)

2.25 (1.94–2.61)

2.57 (2.19–3.02)

 Humerus

220

19.28 (16.90–22.01)

693

15.50 (14.38–16.69)

1.25 (1.07–1.45)

1.63 (1.39–1.91)

 Hip

563

49.35 (45.44–53.60)

1844

41.23 (39.39–43.16)

1.20 (1.10–1.32)

1.45 (1.31–1.60)

 Unspecified

166

14.55 (12.50–16.94)

586

13.10 (12.08–14.21)

1.14 (0.96–1.35)

1.26 (1.06–1.51)

GCA

 Wrist

118

46.80 (39.08–56.06)

356

34.14 (30.77–37.88)

1.37 (1.12–1.68)

1.84 (1.49–2.28)

 Vertebra

72

28.56 (22.67–35.98)

123

11.80 (9.88–14.08)

2.44 (1.84–3.23)

2.97 (2.21–3.99)

 Humerus

35

13.88 (9.97–19.33)

145

13.91 (11.82–16.36)

1.01 (0.70–1.45)

1.19 (0.81–1.73)

 Hip

115

45.61 (37.99–54.76)

419

40.18 (36.51–44.22)

1.16 (0.95–1.42)

1.39 (1.13–1.72)

 Unspecified

31

12.30 (8.65–17.48)

99

9.49 (7.80–11.56)

1.37 (0.91–2.05)

1.32 (0.87–2.00)

  1. aAdjusted for confounding factors which affected the HR > 10%, from age, sex, BMI, alcohol consumption, smoking status, Charlson comorbidity index and PPI use