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Table 3 Incidence rates and hazard ratios (HRs) for associations of site-specific fracture with exposure to polymyalgia rheumatica (PMR) and giant cell arteritis (GCA)

From: Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study

Variables Present Non-present Unadjusted HR (95% CI) Adjusted HR (95% CI)a
  Number with fracture Rate per 10,000 person-years (95% CI) Number with fracture Rate per 10,000 person-years   
PMR
 Wrist 464 40.67 (37.14–44.55) 1568 35.06 (33.37–36.84) 1.16 (1.05–1.29) 1.70 (1.52–1.90)
 Vertebra 276 24.19 (21.50–27.22) 482 10.78 (9.86–11.78) 2.25 (1.94–2.61) 2.57 (2.19–3.02)
 Humerus 220 19.28 (16.90–22.01) 693 15.50 (14.38–16.69) 1.25 (1.07–1.45) 1.63 (1.39–1.91)
 Hip 563 49.35 (45.44–53.60) 1844 41.23 (39.39–43.16) 1.20 (1.10–1.32) 1.45 (1.31–1.60)
 Unspecified 166 14.55 (12.50–16.94) 586 13.10 (12.08–14.21) 1.14 (0.96–1.35) 1.26 (1.06–1.51)
GCA
 Wrist 118 46.80 (39.08–56.06) 356 34.14 (30.77–37.88) 1.37 (1.12–1.68) 1.84 (1.49–2.28)
 Vertebra 72 28.56 (22.67–35.98) 123 11.80 (9.88–14.08) 2.44 (1.84–3.23) 2.97 (2.21–3.99)
 Humerus 35 13.88 (9.97–19.33) 145 13.91 (11.82–16.36) 1.01 (0.70–1.45) 1.19 (0.81–1.73)
 Hip 115 45.61 (37.99–54.76) 419 40.18 (36.51–44.22) 1.16 (0.95–1.42) 1.39 (1.13–1.72)
 Unspecified 31 12.30 (8.65–17.48) 99 9.49 (7.80–11.56) 1.37 (0.91–2.05) 1.32 (0.87–2.00)
  1. aAdjusted for confounding factors which affected the HR > 10%, from age, sex, BMI, alcohol consumption, smoking status, Charlson comorbidity index and PPI use