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Table 3 Negative effects of deprescribing reported to the researchers by GPs in the intervention groupa

From: Deprescribing preventive cardiovascular medication in patients with predicted low cardiovascular disease risk in general practice – the ECSTATIC study: a cluster randomised non-inferiority trial

Negative effects

Participants (n = 42)

Only restarted participants (n = 34)

Times reported

Times reported

Hypertension or increased blood pressure

24

21

Headache or migraine

18

11

Nervous or stressed feeling

7

5

Palpitations

7

5

Ankle oedema or fluid buildup

4

3

Hypercholesterolemia

4

4

Pressure sensation on chest

2

2

Dizziness

2

2

Not feeling well

2

2

Tachycardia

1

1

Systolic cardiac souffle

1

1

Dyspnoea

1

1

Fatigue

1

1

Nausea

1

1

Hot flushes

1

1

Total

76

61

  1. GP general practitioner
  2. aGPs in the usual care group did not report any side effect of antihypertensive or lipid-lowering drugs to the researchers during follow-up