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Table 1 Details of each outcome measure and data source

From: Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Data source Population Outcome Denominator/offset Age in months (m) or years (y) Time period
Alder Hey Children's NHS Foundation Trust RVGE hospitalisations. Alder Hey's footprint covers the majority of Merseyside children Laboratory-confirmed rotavirus gastroenteritis. Rotavirus antigen detected by immunochromatography test (2005–2009) or by enzyme immunoassay (2002–2005 and 2009 onwards) in a faecal specimen of a child with acute gastroenteritis Total hospitalisations per month by age group 0–14 y: < 12 m; 12–23 m; 24–59 m; 5–14 y July 2002 to June 2016
Hospital Episode Statistics – admitted patient care Merseyside residents attending any hospital in England Hospitalisation for all-cause acute gastroenteritis. Identified by ICD-10 codes: A00–A09) or as non-infectious gastroenteritis (K52.9), in any diagnosis field Yearly estimated age-specific population of Merseyside. Source: Office for National Statistics; accessed through Public Health England [16] All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+ July 2000 to June 2016
Hospital Episode Statistics – accident and emergency Merseyside residents attending three major emergency departments in Merseyside Emergency department attendance for gastrointestinal conditions (AE diagnosis code 26); excluding subsequent admissions. Missing diagnosis data was imputed for one emergency department between November 2010 and March 2011 Total emergency department attendances (excluding subsequent admissions) per month by age group All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+ July 2008 to June 2016
Walk-in centre attendance records Attendances at walk-in centres in Wirral, covering an estimated resident population of 320,000 Walk-in centre attendance for infectious gastroenteritis. Read Codes: gastroenteritis – presumed infectious origin (A0812), diarrhoea of presumed infectious origin (A083); infantile viral gastroenteritis (A07y1); infectious gastroenteritis (A0803); enteritis due to rotavirus (A0762); and infectious diarrhoea (A082) All walk-in centre attendances per month by age group All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+ July 2011 to June 2016
GP records Consultations at 136 GP practices in Merseyside, covering an estimated population of 790,000 Consultations for infectious gastroenteritis (Read Codes as above for walk-in centre) Yearly estimated GP registered population by age group. Data were available from 2010 to 2016, therefore estimates for 2007/2008 and 2008/2009 were synthetically estimated using predictions from linear regression models. Source: Public Health England and participating GP practices All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+ July 2007 to June 2016
  1. GP general practice, RVGE rotavirus gastroenteritis, AE accident and emergency