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Table 1 Clinical and demographic characteristics of the study population

From: Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin

  Uncomplicated term delivery Before PPROM P value (UTC vs. before PPROM) After PPROM P value (before PPROM vs. after PPROM) P value all
Total number 20 15   87   
Age (years) 33 (31–34) 34 (30–37) 0.6410 33 (32–34) 0.79 0.9279
Ethnicity n (%)
 Caucasian 10 (50%) 6 (40%)   38 (44%)   
 Black 5 (25%) 3 (20%) 0.6393 20 (23%) 0.8796 0.9207
 Asian 5 (25%) 6 (40%)   29 (33%)   
GA first sample (weeks) 28+2 (28+1–29+0) 32+0 (27+0–34+0) 0.1871 28+1 (25+1–33+0) 0.2743 0.4504
GA at MR (weeks) n/a 34+4 (31+0–35+2)   27+0 (24+6–32+4) 0.0011  
GA at delivery (weeks) 40+1 (39+2–41+1) 34+4 (31+0–35+2) 6.12 × 10-7 30+4 (26+5–34+2) 0.0142 <0.0001
Apgar score
 1 min 9 (8–9)* 9 (8–9)* 0.6432 6 (5–9)** 0.0013 <0.0001
 5 min 10 (10–10)* 9 (9–10)* 0.0656 8 (7–9)** 0.0183 <0.0001
BW (g) 3400 (3215–3980)* 2285 (1720–2560) 0.000005 1550 (877.5–2216) 0.0140 <0.0001
Admission to neonatal unit 0 (0%) 3 (20%) 0.069519 59 (68%) 0.00094 <0.0001
Latency
 PPROM to delivery (days) n/a 1 (0–4)   4 (2–9) 0.0212  
  1. Data presented as median (interquartile range) or number (%)
  2. BMI body mass index, BW birth weight, GA gestational age, MR membrane rupture, n/a not applicable, PPROM Preterm prelabour rupture of the fetal membranes
  3. P values: t-test/Mann–Whitney U (depending upon distribution), Fisher’s exact for proportional data, ANOVA for multiple comparisons
  4. Missing data * n = 5, **n = 15