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Fig. 2 | BMC Medicine

Fig. 2

From: The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester

Fig. 2

Intra-adrenal steroid levels in the human fetal adrenal during the second trimester. Steroid levels, expressed as ng/mg of tissue, are shown for each steroid measured (n = 60) and are arranged within the canonical steroidogenic pathways. The enzymes responsible for each conversion are shown in grey boxes. Data points from individual fetuses are shown, and the limit of quantitation for each steroid is shown as a horizontal line. Aldosterone, 17α-hydroxypregnenolone, DHEA and androstenedione were not detectable in any of the 60 samples. *The conversion of 11-deoxycorticosterone to aldosterone by CYP11B2 occurs via corticosterone and 18-hydroxycorticosterone as intermediates

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