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Table 1 Results of ARTP-based gene analysis. Circadian genes statistically significantly associated with risk of cancer (all cases) are listed (ordered by increasing P value) along with the number of single nucleotide polymorphisms (SNPs) included in the analysis

From: Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

Gene

Chromosome

No. SNPs

P value

Cancer

RORA

15

8

2.95E-04

Breast_all cases

PER1

17

2

3.34E-04

RORB

9

5

6.49E-04

ARNTL

11

1

0.002

CRY2

11

1

0.002

CLOCK

4

1

0.006

CRY1

12

1

0.008

RORC

1

1

0.010

ARNTL

11

1

2.04E-04

Prostate_all cases

RORA

15

6

2.32E-04

NPAS2

2

6

0.002

RORB

9

1

0.005

NR1D1

17

1

0.005

PER3

1

1

0.009

CLOCK

4

1

0.010

RORA

15

27

2.00E-06

Lung_all cases

RORB

9

11

9.39E-05

ARNTL

11

17

5.94E-04

NPAS2

2

5

7.89E-04

CSNK1E

22

4

7.97E-04

PER3

1

3

0.002

PER2

2

2

0.002

CLOCK

4

3

0.003

CRY1

12

2

0.007

CRY2

11

1

0.008

NR1D1

17

2

0.017

ARNTL2

12

1

0.028

NR1D2

3

1

0.046