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Table 2 Study characteristics

From: Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease

Cohort Number of Events Number of patients Person years Mean age, years Men, % Mean FEV1%pred. Mean mMRC Past exacerbators, % Mean no. prev. exacerbations Current smoker, % Mean BMI Mean 6MWT, m Mean SGRQ Mean CAT
COPDgene 337 4484 10,603 63 (9) 56 57.4 (22.8) 1.5 0.16   43 27.9 (6.1) 376.1 (124.1) 36.9 (22.9)  
Sevillaa 205 596 1562 66 (10) 95 43.5 (13.3) 1 0.25 1.16 24 29.2 (5.7)    
Copenhagenb 186 2287 6618 61 (9) 54 70.5 (23.7) 1.3    71 25 (4.2)    
Genkols 126 954 2708 65 (10) 61 46.9 (17) 1.3 0.15 0.6 47 25.4 (5)    
Zaragoza IIa 118 1150 3069 63 (9) 93 62.3 (20.3) 1.1 0.17 0.91 34 27.5 (4.8) 356.2 (153.7)   
HUNT 116 1571 4583 63 (13) 62 63.8 (18.7) 1.3    47 26.4 (4.4)    
Galdakaoa 92 543 1497 68 (8) 96 55 (13.3) 0.9 0 0.65 21 28.3 (4.4) 408.9 (92.4)   
Barmelweidb 79 232 555 72 (9) 60 45.2 (16.1) 1.1    21 26 (6.3) 363.4 (126.8)   
Terrassa IIIa 78 181 423 72 (10) 95 45.2 (14.4) 1.2 0.31 1.28 23 27.9 (5) 330.4 (105.8)   
Initiatives BPCO 76 930 1525 64 (10) 77 52.4 (20.3) 1.1 0.4 1.65 28 25.4 (5.5) 387.4 (120.8) 43.9 (19)  
Terrassa Ia 72 135 284 72 (9) 92 41.3 (13) 1.3 0.25 1.03 17 26.3 (4.9)    
SEPOCb 61 318 871 65 (9) 100 45 (18.3) 1.5    38 26.4 (4.2)    
Requena IIa,c 52 186 396 71 (9) 99 44.5 (16.5) 1 0.16 0.62 17 28.1 (5.2) 380.1 (111.9)   
ICE COLD ERIC 47 400 1071 67 (10) 57 55.3 (16.5) 1.5 0.13 0.58 39 26.1 (5.2)    
PAC-COPDb 41 342 980 68 (9) 93 52.4 (16.2) 1 0.04   33 28.2 (4.7) 435.5 (90.6)   
Tenerifea 34 275 653 63 (10) 79 55.8 (21.2) 1.2 0.06 0.37 42 27.3 (5.1) 487.4 (87.5)   
Terrassa IIa 28 66 145 72 (9) 98 30.2 (12.9) 1 0.42 1.81 14 25.7 (4.3) 217.7 (76.6)   
Requena Ia 23 174 393 72 (9) 99 48.1 (16.8) 1.2c 0.03 0.22 23 28 (4.2) 434.4 (125.3)   
Zaragoza Ia 21 137 379 66 (8) 99 49.8 (17.6) 1.1    27 27.7 (4.6) 449 (91.9)   
Son Espases Mallorca 17 115 292 70 (7) 79 41.5 (13.4) 1 0.59   27 27.1 (5.9) 401.5 (89.7)   16.6 (8.2)
Basqueb 16 106 299 71 (9) 98 46.9 (11.4) 0.6    23 26.1 (4.9) 442.9 (95.4)   
Japan 15 147 409 69 (7) 100 47.1 (17.5) 0.9    22 21 (2.9)   36.6 (16.5)  
La Princesa Madrid 11 318 633 71 (10) 74 50 (19.8) 1.1 0.18 0.77 19 26.2 (5.1) 337.1 (92.8)   
Pamplonaa 7 190 470 65 (8) 84 68.9 (19.9) 1.1    37 27 (4.4) 463.2 (113.9)   
Mar de Plata Argentina 3 99 147 64 (9) 60 48.8 (18.6) 1 0.29   21 27 (5.6) 353.2 (128.7)   16.1 (7.8)
A1ATDd 0 308 834 58 (10) 60 53.1 (25.1) 1.2 0.52   5 25.7 (4.9)   50.8 (19.9) 20.5 (8.1)
  1. Abbreviations: FEV1% pred. forced expiratory volume in 1 s percentage predicted, mMRC modified Medical Research Council (MMRC) dyspnea scale; past exacerbators are defined as patients with more than one exacerbation in the previous year; mean number previous exacerbations are referred to the previous year, BMI body mass index, 6MWT 6-min walk test, SGRQ Saint George’s Respiratory Questionnaire, CAT COPD Assessment Test
  2. The cohorts are presented in decreasing order of number of events. Most of the variables available provided by the 3CIA collaboration for the different cohorts are shown. In particular, we show all the variables constituting the scores analyzed in our study. We present the standard deviation for all individual variables whose distribution is approximately normal; this is not the case for count (with small numbers) or categorical variables, like number of previous exacerbations or mMRC)
  3. aCohorts belonging to the Collaborative Cohorts to Assess Multicomponent Indices of COPD in Spain (COCOMICS) collaboration
  4. bCohorts belonging to the ADO collaboration. For information concerning the cohorts, see [49]
  5. cSince none of the scores could be evaluated in the cohort Requena I (mainly because the variable dyspnoea was missing for 95% of the patients, i.e., for 165 out of 174 patients), this cohort was excluded from the analysis
  6. dSince there was no event in a follow-up of 3 years, the cohort A1ATD was excluded from the analysis
  7. Missing cells correspond to variables that are completely missing in the cohort of the correspondent row
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