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Table 3 Lactate clearances within first 8 h of randomisation in survivors and non-survivors at 72 h

From: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa

  Survivors Non-survivors Total Unadjusted OR of death (95% CI) p valuea
Lactate clearance at 8 h amongst children with an abnormal lactate on admission ≥ 2.5 mmol/Lb
 Number, N (%) 1792 (94) 114 (6) 1906
 Lactate at 8 h (mmol/L); median (IQR)c 3.3 (2.3, 5) 5.4 (3.4, 10) 3.4 (2.3, 5.1) < 0.001d
 Absolute LC (mmol/L); median (IQR)c 1.7 (0.2, 4.5) 1.3 (−0.5, 4.7) 1.6 (0.1, 4.6) 0.12d
 Relative LC (%); median (IQR)c 37 (3.7, 59.5) 17 (−6, 51) 36 (3.33, 59) 0.003d
 Relative LC < 10% 516/1792 (29) 50/114 (44) 566/1906 (30) 1.93 (1.31, 2.84) < 0.001
 Relative LC ≥ 40% 840/1792 (47) 38/114 (33) 878/1906 (46) 0.57 (0.38, 0.85) < 0.01
 Lactate normalisatione 540/1792 (30) 14/114 (12) 554/1906 (29) 0.33 (0.18, 0.57) < 0.001
 Relative LC ≥ 40% and/or lactate normalisation 973/1792 (54) 41/114 (36) 1014/1906 (53) 0.47 (0.32, 0.70) < 0.001
Lactate clearance at 8 h amongst those with lactate on admission ≥ 5 mmol/Lf
 N (%) 919 (92) 85 (8) 1004
 Lactate at 8 h; median (IQR)c 3.9 (2.7, 6) 6.8 (4.1, 11.3) 4.1 (2.8, 6.3) < 0.001d
 Absolute LC (mmol/L); median (IQR)c 4.4 (2.4, 7.7) 2.3 (0, 5.8) 4.3 (2.3, 7.6) < 0.001d
 Relative LC (%); median (IQR)c 55 (32, 71) 23 (0, 62) 54 (28, 70) < 0.001d
 Relative LC < 10% 116 /919(13) 33/85 (39) 149/1004 (15) 4.40 (2.70, 7.16) < 0.001
 Relative LC ≥ 40% 628/919 (68) 33/85 (39) 661/1004 (66) 0.29 (0.18, 0.47) < 0.001
 Lactate normalisatione 200/919 (22) 6/85 (7) 206/1004 (21) 0.27 (0.12, 0.64) 0.001
 Relative LC ≥ 40% and/or lactate normalisation 628/919 (68) 33/85 (39) 661/1004 (66) 0.29 (0.18, 0.47) < 0.001
  1. aChi-squared test p values
  2. bTotal of 811 children with normal lactate levels on admission (< 2.5 mmol/L) excluded
  3. cRef: Reference group
  4. dWilcoxon rank-sum test p values
  5. eLactate decline < 2.5 mmol/L in the first 8 h after randomisation
  6. f1713 children with lactate levels on admission < 5 mmol/L excluded