Table 3 Lactate clearances within first 8 h of randomisation in survivors and non-survivors at 72 h

 Number, N (%)

1792 (94)

114 (6)

1906

–

–

 Lactate at 8 h (mmol/L); median (IQR)^c

3.3 (2.3, 5)

5.4 (3.4, 10)

3.4 (2.3, 5.1)

–

< 0.001^d

 Absolute LC (mmol/L); median (IQR)^c

1.7 (0.2, 4.5)

1.3 (−0.5, 4.7)

1.6 (0.1, 4.6)

–

0.12^d

 Relative LC (%); median (IQR)^c

37 (3.7, 59.5)

17 (−6, 51)

36 (3.33, 59)

–

0.003^d

 Relative LC < 10%

516/1792 (29)

50/114 (44)

566/1906 (30)

1.93 (1.31, 2.84)

< 0.001

 Relative LC ≥ 40%

840/1792 (47)

38/114 (33)

878/1906 (46)

0.57 (0.38, 0.85)

< 0.01

 Lactate normalisation^e

540/1792 (30)

14/114 (12)

554/1906 (29)

0.33 (0.18, 0.57)

< 0.001

 Relative LC ≥ 40% and/or lactate normalisation

973/1792 (54)

41/114 (36)

1014/1906 (53)

0.47 (0.32, 0.70)

< 0.001

 N (%)

919 (92)

85 (8)

1004

–

–

 Lactate at 8 h; median (IQR)^c

3.9 (2.7, 6)

6.8 (4.1, 11.3)

4.1 (2.8, 6.3)

–

< 0.001^d

 Absolute LC (mmol/L); median (IQR)^c

4.4 (2.4, 7.7)

2.3 (0, 5.8)

4.3 (2.3, 7.6)

–

< 0.001^d

 Relative LC (%); median (IQR)^c

55 (32, 71)

23 (0, 62)

54 (28, 70)

–

< 0.001^d

 Relative LC < 10%

116 /919(13)

33/85 (39)

149/1004 (15)

4.40 (2.70, 7.16)

< 0.001

 Relative LC ≥ 40%

628/919 (68)

33/85 (39)

661/1004 (66)

0.29 (0.18, 0.47)

< 0.001

 Lactate normalisation^e

200/919 (22)

6/85 (7)

206/1004 (21)

0.27 (0.12, 0.64)

0.001

 Relative LC ≥ 40% and/or lactate normalisation

628/919 (68)

33/85 (39)

661/1004 (66)

0.29 (0.18, 0.47)

< 0.001